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Localized <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> is likely to resolve spontaneously, while generalized <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">GGA<\/jats:styled-content>) is rare and may persist for decades. <jats:styled-content style=\"fixed-case\">GGA<\/jats:styled-content> usually is resistant to a variety of therapeutic modalities and takes a chronic course. The objective of this study was to summarize all reported treatments of generalized granuloma annulare. This is a systematic review based on <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Embase and Cochrane Central Register search of articles in English and German and a manual search, between 1980 and 2013, to summarize the treatment of generalized granuloma annulare. Most medical literature on treatment of <jats:styled-content style=\"fixed-case\">GGA<\/jats:styled-content> is limited to individual case reports and small series of patients treated without a control group. Randomized controlled clinical studies are missing. Multiple treatment modalities for <jats:styled-content style=\"fixed-case\">GGA<\/jats:styled-content> were reported including topical and systemic steroids, <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>, isotretinoin, dapsone, pentoxifylline, hydroxychloroquine, cyclosporine, <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3, potassium iodide, nicotinamide, niacinamide, salicylic acid, dipyridamole, <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, fumaric acid ester, etanercept, infliximab, adalimumab. While there are numerous case reports of successful treatments in the literature including surgical, medical and phototherapy options, well\u2010designed, randomized, controlled clinical trials are required for an evidence\u2010based treatment of <jats:styled-content style=\"fixed-case\">GGA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jdv.12976","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T10:49:16Z","timestamp":1423046956000},"page":"1467-1480","source":"Crossref","is-referenced-by-count":79,"title":["Treatment of generalized granuloma annulare \u2013 a systematic review"],"prefix":"10.1111","volume":"29","author":[{"given":"J.","family":"Luk\u00e1cs","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schliemann","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital 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