{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:46:04Z","timestamp":1792788364729,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Folliculitis decalvans (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) is a rare neutrophilic scarring alopecia that represents a therapeutic challenge for dermatologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the epidemiology, comorbidities, clinical presentation, diagnostic findings and therapeutic options in a large series of patients with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective multicentre review includes patients diagnosed with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> based on clinical and histopathologic findings. The clinical severity was determined by the maximum diameter of the largest alopecic patch (slight: &lt;2\u00a0cm, moderate: 2\u20134.99\u00a0cm, severe: 5\u00a0cm or more). Response to therapy was assessed as improvement, worsening or stabilization depending on the clinical symptoms (pruritus and trichodynia), inflammatory signs (erythema, pustules and crusts) and the extension of the alopecic patch.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 82 patients (52 males and 30 females) with a mean age of 35\u00a0years were included. No significant comorbidities were present. A family history was present in three males. Severe <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> was observed in 17 patients (21%). The independent factors associated with severe <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> after multivariate analysis were: onset of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> before 25\u00a0years of age and presence of pustules. Oral antibiotics (tetracyclines and the combination of clindamycin and rifampicin) improved 90% and 100% of the patients, with a mean duration of response of 4.6 and 7.2\u00a0months respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The onset of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> before 25\u00a0years of age and the presence of pustules within the alopecic patch were associated with severe <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. Tetracyclines and the combination of clindamycin and rifampicin were the most useful treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12993","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T11:04:09Z","timestamp":1423825449000},"page":"1750-1757","source":"Crossref","is-referenced-by-count":98,"title":["Folliculitis decalvans: a multicentre review of 82 patients"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Va\u00f1\u00f3\u2010Galv\u00e1n","sequence":"first","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal IRYCIS Universidad de Alcal\u00e1 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Molina\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Jim\u00e9nez Diaz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fern\u00e1ndez\u2010Crehuet","sequence":"additional","affiliation":[{"name":"Alto Guadalquivir de And\u00fajar Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Rodrigues\u2010Barata","sequence":"additional","affiliation":[{"name":"Grupo Pedro Ja\u00e9n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arias\u2010Santiago","sequence":"additional","affiliation":[{"name":"Unidad de Dermatolog\u00eda Hospital Virgen de las Nieves Instituto de Investigaciones Biosanitarias IBS Hospitales Universitarios de Granada\/Universidad de Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Serrano\u2010Falc\u00f3n","sequence":"additional","affiliation":[{"name":"Guadix Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Martorell\u2010Calatayud","sequence":"additional","affiliation":[{"name":"Manises Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Barco","sequence":"additional","affiliation":[{"name":"Teknon Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal IRYCIS Universidad de Alcal\u00e1 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Universidad de Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Requena","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Jim\u00e9nez Diaz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Grimalt","sequence":"additional","affiliation":[{"name":"Universitat Internacional de Catalunya Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Paoli","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ja\u00e9n","sequence":"additional","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal IRYCIS Universidad de Alcal\u00e1 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Camacho","sequence":"additional","affiliation":[{"name":"Virgen Macarena Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02675.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00746.x"},{"key":"e_1_2_6_4_1","first-page":"395","article-title":"Folliculite \u00e9pilante et destructive des r\u00e9gions velues","volume":"5","author":"Quinquaud E","year":"1888","journal-title":"Bull Mem Soc Med Paris"},{"key":"e_1_2_6_5_1","first-page":"376","article-title":"Casanova\u2010Seuma JM [Scarring alopecia]","volume":"103","author":"Abal\u2010Diaz L","year":"2012","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03564.x"},{"key":"e_1_2_6_7_1","first-page":"162","article-title":"Folliculitis decalvans treated with radiation therapy","volume":"78","author":"Smith EP","year":"2006","journal-title":"Cutis"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03616.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02216.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.66908"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12448"},{"key":"e_1_2_6_12_1","first-page":"84","article-title":"Folliculitis decalvans\u2013a retrospective study in a tertiary referred centre, over five years","volume":"44","author":"Chandrawansa PH","year":"2003","journal-title":"Singapore Med J"},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"Retrospective review of folliculitis decalvans in 23 patients with course and treatment analysis of long\u2010standing cases","volume":"18","author":"Bunagan MJ","year":"2014","journal-title":"J Cutan Med Surg"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00204.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.070"},{"key":"e_1_2_6_16_1","first-page":"216","article-title":"Folliculitis decalvans in a family","volume":"66","author":"Jaiswal AK","year":"2000","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_6_17_1","first-page":"133","article-title":"Folliculitis decalvans and cellular immunity \u2010two brothers with oral candidiasis","volume":"28","author":"Shitara A","year":"1974","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03852.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12083"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02882.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1983.tb01104.x"},{"key":"e_1_2_6_22_1","first-page":"373","article-title":"Folliculitis decalvans and tufted folliculitis are specific infective diseases that may lead to scarring, but are not a subset\u00a0of central centrifugal scarring alopecia","volume":"137","author":"Powell J","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.2.235"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(04)93570-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00639.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05212.x"},{"key":"e_1_2_6_27_1","first-page":"74","article-title":"Therapy\u2010resistant folliculitis decalvans and lichen planopilaris successfully treated with adalimumab","volume":"12","author":"Kreutzer K","year":"2014","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2012.07972_suppl.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.826340"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30344.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12993","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:12:45Z","timestamp":1695492765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,12]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/jdv.12993"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12993","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,12]]}}}