{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:25:10Z","timestamp":1767968710861,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have shown that patients with bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) are more likely to have neurological diseases (<jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare clinical findings in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients with and without <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> and to investigate <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 autoantibody binding in different neuronal tissues of mammalians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our database was searched for clinical findings of in\u2010patients with the definitive diagnosis of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Moreover, brain tissue of mammalians was treated with serum of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients with elevated <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 autoantibodies using biochip mosaics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 85\/161 (52.8%) patients had a history of at least one <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), eosinophils (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) and patients' accommodation in nursing homes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) remained in the logistic regression model as significant independent predictors for the presence of <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Subgroup analysis of community\u2010dwelling <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients revealed 25\/93 (26.9%) patients with <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>. In this population, the presence of <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> also significantly correlated with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.26; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0003) and eosinophils (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.19; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0087). In the animal model, no <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180\u2010specific immunofluorescence could be detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data support results of previous studies detecting significantly increased frequency of <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients. We have shown that raised <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 titres and blood eosinophils are independent predictors for the presence of <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients. However, our experimental data do not support previous results indicating that specific binding of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 antibodies in neuronal tissue plays a pathogenetic role in <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12995","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T10:53:02Z","timestamp":1423047182000},"page":"1758-1762","source":"Crossref","is-referenced-by-count":33,"title":["Neurological disorders in patients with bullous pemphigoid: clinical and experimental investigations"],"prefix":"10.1111","volume":"29","author":[{"given":"T.","family":"Gambichler","sequence":"first","affiliation":[{"name":"Department of Dermatology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Segert","sequence":"additional","affiliation":[{"name":"Department of 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