{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T03:34:44Z","timestamp":1775964884607,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Galderma, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Daylight photodynamic therapy (DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content>) with methyl aminolevulinate (MAL<\/jats:styled-content>) is a simplified PDT<\/jats:styled-content> procedure that was recently shown in a few trials to be effective for grade I actinic keratosis (AK<\/jats:styled-content>), with improved tolerability and reduced time of clinical attendance as compared to conventional PDT<\/jats:styled-content> (c\u2010PDT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate the efficacy and tolerability of DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> vs. c\u2010PDT<\/jats:styled-content> with MAL<\/jats:styled-content> in the treatment of grade I AK<\/jats:styled-content> on the face and scalp in Italy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty\u2010five patients with AK<\/jats:styled-content>s on the face (n<\/jats:italic>\u00a0=\u00a017) or scalp (n<\/jats:italic>\u00a0=\u00a018) were prospectively enrolled in an intra\u2010patient, left\u2010right, prospective, comparison study between DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> and c\u2010PDT<\/jats:styled-content> at a single centre between September and October 2013. Weather conditions and outdoor temperature during daylight exposure were recorded for each DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> session. Pain was assessed after the PDT<\/jats:styled-content> session and local adverse events 2\u00a0days after treatment. Lesion response rate was evaluated on both sides at 3\u00a0months. AK<\/jats:styled-content>s with complete regression were followed until 6\u00a0months. Patient's preference for either treatment was recorded.<\/jats:p><\/jats:sec>Results<\/jats:title>There was no difference in complete response (CR<\/jats:styled-content>) rate of AK<\/jats:styled-content> I at 3\u00a0months between DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> and c\u2010PDT<\/jats:styled-content> (87% vs. 91%; RR<\/jats:styled-content>\u00a0=\u00a00.96; P<\/jats:italic>\u00a0=\u00a00.16). A lower CR<\/jats:styled-content> rate was observed with DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> than with c\u2010PDT<\/jats:styled-content> for AK II<\/jats:styled-content> (36% vs. 61%; RR<\/jats:styled-content>\u00a0=\u00a00.58, P<\/jats:italic>\u00a0=\u00a00.06) and III<\/jats:styled-content> (25% vs. 46%; RR<\/jats:styled-content>\u00a0=\u00a00.50, P<\/jats:italic>\u00a0=\u00a00.20). Recurrence rate at 6\u00a0months was slightly higher for cleared AK<\/jats:styled-content> I after DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> than after c\u2010PDT<\/jats:styled-content> (17% vs. 12%, RR<\/jats:styled-content>\u00a0=\u00a01.50, P<\/jats:italic>\u00a0<\u00a00.05). DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> was associated with lower pain (\u0394VAS<\/jats:styled-content>\u00a0=\u00a0\u22122.2, P<\/jats:italic>\u00a0<\u00a00.01) and reduced severity of local adverse events (\u0394LSR<\/jats:styled-content>\u00a0=\u00a0\u22121.4, P<\/jats:italic>\u00a0<\u00a00.01) than c\u2010PDT<\/jats:styled-content>. Increasing outdoor temperature was associated with the efficacy of DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> and the severity of adverse events. DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> was preferred by 88% of the patients.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>MAL DL\u2010PDT<\/jats:styled-content> showed similar efficacy to c\u2010PDT<\/jats:styled-content> in the treatment of AK<\/jats:styled-content> I of the face\/scalp but was less effective than c\u2010PDT<\/jats:styled-content> for AK<\/jats:styled-content>s II<\/jats:styled-content> and III<\/jats:styled-content>. DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> was better tolerated being associated with lower pain and occurrence of fewer adverse events. Clinical response to DL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> was significantly moderated by outdoor temperature, increasing at higher temperatures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13076","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T19:44:08Z","timestamp":1427226248000},"page":"1926-1932","source":"Crossref","is-referenced-by-count":62,"title":["Conventional vs. daylight methyl aminolevulinate photodynamic therapy for actinic keratosis of the face and scalp: an intra\u2010patient, prospective, comparison\u00a0study in Italy"],"prefix":"10.1111","volume":"29","author":[{"given":"M.C.","family":"Fargnoli","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L'Aquila L'Aquila Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Piccioni","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L'Aquila L'Aquila 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