{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T20:00:29Z","timestamp":1774296029232,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007365","name":"Fondazione IRCCS Policlinico San Matteo","doi-asserted-by":"publisher","award":["556"],"award-info":[{"award-number":["556"]}],"id":[{"id":"10.13039\/100007365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) is the most common cutaneous T\u2010cell lymphoma. We previously reported that the prognosis of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients is not only related on clinical variables but it is also associated with peculiar <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles. Until today, the association of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> ligands for <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> with the prognosis of the disease has not yet been analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated the frequency of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> ligands for killer cell Immunoglobulin\u2010like receptors (<jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content>s) in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients, evaluating if the presence of particular <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles that are ligands for <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> may have prognostic value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study includes 46 Caucasian <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients that, between 1993 and 1997, underwent <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genomic typing. All patients were diagnosed and followed up from 1977 to 2012 (mean follow\u2010up of 11\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients have been divided into two groups (long survivors and dead patients). We noticed that the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010Bw6\/Bw6 specificity increased among the group of seven dead patients compared to the group of 39 long survivors (71.4% vs. 41.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0ns, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.59), while in the long survivors group the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010 Bw4\/Bw4 specificity increased when compared to dead patients (23.0% vs. 0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0ns). Moreover, we observed that six of the seven dead patients had <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*05; the phenotypic frequency of this <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> allele, in dead and long survivors patients, was 85.7% and 23.0% respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our observations suggest that the presence of the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*05 alleles characterizes the patients with the poorest prognosis in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>. In addition, absence of the <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content>\u2010ligand epitope <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B Bw4 showed a trend of being more prominent in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients with the poorest prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13083","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T07:45:32Z","timestamp":1425887132000},"page":"266-269","source":"Crossref","is-referenced-by-count":8,"title":["Mycosis fungoides: association of <scp>KIR<\/scp> ligands and <scp>HLA<\/scp>\u2010<scp>DQB<\/scp>1*05 with bad prognosis of the disease"],"prefix":"10.1111","volume":"30","author":[{"given":"V.","family":"Brazzelli","sequence":"first","affiliation":[{"name":"Department of Clinical\u2010Surgical, Diagnostic and Pediatric Science Institute of Dermatology Pavia 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