{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:08:44Z","timestamp":1762506524147},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The discovery, from 2007, of eight new human polyomaviruses (HPyVs) has revived interest in the Polyomaviridae<\/jats:italic> family and their association with human diseases and cancer. In particular, HP<\/jats:styled-content>yV6 and HP<\/jats:styled-content>yV7 were discovered in skin swabs of healthy donors and TSP<\/jats:styled-content>yV was discovered in a heart transplant recipient affected by virus\u2010associated Trichodysplasia Spinulosa (TS<\/jats:styled-content>), a rare skin disease, exclusively found in immunocompromised patients.<\/jats:p><\/jats:sec>Objective<\/jats:title>The presence of HP<\/jats:styled-content>yV6, HP<\/jats:styled-content>yV7 and TSP<\/jats:styled-content>yV DNA<\/jats:styled-content> in skin biopsies from patients affected by different skin diseases (cancers and inflammatory disorders) has been evaluated to confirm their skin tropism and the possible pathological association.<\/jats:p><\/jats:sec>Methods<\/jats:title>DNA<\/jats:styled-content> extracted was amplified with HP<\/jats:styled-content>yV6, HP<\/jats:styled-content>yV7 and TSP<\/jats:styled-content>yV specific PCR<\/jats:styled-content> real time on Taqman platform with standard profile.<\/jats:p><\/jats:sec>Results<\/jats:title>HP<\/jats:styled-content>yV7 and TSP<\/jats:styled-content>yV sequences were not found in any skin specimen analysed. HP<\/jats:styled-content>yV6, on the other hand, was detected in 30% of samples from healthy subjects vs. 14.3% of skin cancer patients and 2.9% of inflammatory disorders. HP<\/jats:styled-content>yV6 sequences have been detected in primary cutaneous T\u2010cell lymphoma (CTCL<\/jats:styled-content>) patients (in 18.6% out of Mycosis Fungoides (MF<\/jats:styled-content>) patients and in 16.7% out of CTCL<\/jats:styled-content> not MF<\/jats:styled-content>\/SS<\/jats:styled-content>(S\u00e8zary syndrome) but have not been detected in primary cutaneous B\u2010cell lymphoma (CBCL<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our preliminary data suggest that these three novel human polyomaviruses seem not to play a significant role neither in the pathogenesis of cutaneous malignancies nor in that of inflammatory disorders but, according to literature, can inhabit the skin. On the basis of our data regarding the HP<\/jats:styled-content>yV6 DNA<\/jats:styled-content> presence with decreasing percentages in healthy subjects, skin cancer and inflammatory disorders patients, it could be an intriguing matter to study if the activated innate immune response in inflammatory disorders can suppress the virus. Further investigations are needed to better understand their relationship with the human host and its innate immune system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13094","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T19:46:05Z","timestamp":1427226365000},"page":"624-627","source":"Crossref","is-referenced-by-count":27,"title":["HP<\/scp>yV6, HP<\/scp>yV7 and TSP<\/scp>yV DNA<\/scp> sequences detection in skin disease patients and healthy subjects"],"prefix":"10.1111","volume":"30","author":[{"given":"P.","family":"Fava","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Dermatology Section Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Merlino","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatrics Microbiology Section Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Novelli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Dermatology Section Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ponti","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Dermatology Section Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Galliano","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediactrics Cytoimmunodiagnostic Laboratory University of Torino Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Montanari","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediactrics Cytoimmunodiagnostic Laboratory University of Torino Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Tovo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediactrics Cytoimmunodiagnostic Laboratory University of Torino Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Fierro","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Dermatology Section Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bergallo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediactrics Cytoimmunodiagnostic Laboratory University of Torino Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.12.015"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.05.006"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001024"},{"key":"e_1_2_5_5_1","first-page":"639","article-title":"DNA from human polyomaviruses, TSPyV, MWPyV, HPyV6, 7 and 9 was not detected in primary mucosal melanomas","volume":"34","author":"Ramqvist T","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_5_6_1","first-page":"1355","article-title":"Seroprevalence of trichodysplasia spinulosa\u2010associated polyomavirus","volume":"17","author":"Van der Meijden E","year":"2011","journal-title":"Emerg Infect 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