{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:54:13Z","timestamp":1788893653493,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Microcystic adnexal carcinoma (MAC<\/jats:styled-content>), syringomatous carcinoma (SC<\/jats:styled-content>) and \u201cSquamoid eccrine ductal carcinoma\u201d (SEDC<\/jats:styled-content>) are rare sclerosing adnexal tumours.<\/jats:p><\/jats:sec>Objective<\/jats:title>To understand the histogenesis of these tumours and possible clinical implications.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a retrospective study of 30 cases, 18 MAC<\/jats:styled-content>, 5 SC<\/jats:styled-content> and 7 SEDC<\/jats:styled-content> reviewed and classified by a panel of dermatopathology experts, with immunohistochemical analysis of keratins, including K77, a new keratin specific of eccrine ducts, and PHLDA<\/jats:styled-content>1 expressed in adnexal structures.<\/jats:p><\/jats:sec>Results<\/jats:title>There was a strong female predominance, with only five cases occurring in men. Patients with MAC<\/jats:styled-content> and SC<\/jats:styled-content> were younger (mean age 56 and 47\u00a0years) than those with SEDC<\/jats:styled-content> (mean age 81\u00a0years). The most common localization was the cheek in SC<\/jats:styled-content> and SEDC<\/jats:styled-content> and the periocular area in MAC<\/jats:styled-content>. Two cases of SEDC<\/jats:styled-content> were found in organ transplant patients. No recurrence or metastases were observed after complete surgery of MAC<\/jats:styled-content>, or SC<\/jats:styled-content> (mean follow\u2010up 7.2\u00a0years and 4.7\u00a0years), whereas one case of SEDC<\/jats:styled-content> recurred and another could not be fully excised. MAC<\/jats:styled-content> and SC<\/jats:styled-content> had similar histological features, except for cysts. In MAC<\/jats:styled-content>, calcifications, granulomas, connection to follicles, keratin expression pattern, PHLDA<\/jats:styled-content>1 positivity and K77 negativity indicated a follicular histogenesis, whereas in SC<\/jats:styled-content>, K77 positivity and keratin expression pattern were consistent with a differentiation towards eccrine apparatus. SEDC<\/jats:styled-content> was composed of strands centred by ducts and nests with squamous differentiation and displayed K77 ductal positivity in all cases, a finding consistent with an eccrine origin.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study demonstrated that MAC<\/jats:styled-content> and SC<\/jats:styled-content> have similar clinical characteristics, although histogenesis differs and show arguments for the individualization of SEDC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13127","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T07:16:58Z","timestamp":1429082218000},"page":"1978-1994","source":"Crossref","is-referenced-by-count":50,"title":["Anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas (microcystic adnexal carcinoma, syringomatous carcinoma and squamoid eccrine ductal 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