{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:00:27Z","timestamp":1789884027815,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accurate and reliable assessment of changes in psoriasis severity is critical in clinical trials of therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare Psoriasis Area and Severity Index (PASI), static Physician's Global Assessment (sPGA), and the Lattice System Physician's Global Assessment (LS\u2010PGA) in a trial of systemic treatments for plaque psoriasis vulgaris and to assess whether they measure change in psoriasis induced by therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomized to voclosporin or cyclosporine for 24\u00a0weeks (the \u201824\u2010week\u2010treatment\u2019 group, <jats:italic>n<\/jats:italic>\u00a0=\u00a0366), or placebo for 12\u00a0weeks followed by voclosporin for 12\u00a0weeks (the \u2018initial\u2010placebo\u2019 group, <jats:italic>n<\/jats:italic>\u00a0=\u00a089).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All scoring systems changed in concert and were sensitive enough to detect reductions in severity during placebo therapy as well as with active therapy (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01 for each measurement). At study onset, there were poorer correlations of sPGA with PASI (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.45) and LS\u2010PGA (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.39) than between PASI and LS\u2010PGA (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.68). After therapy, all correlations were stronger, but sPGA continued to be less well correlated (with PASI, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.85; with LS\u2010PGA, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.79) than LS\u2010PGA with PASI (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.90). Two\u2010 or three\u2010step improvements in LS\u2010PGA showed very good to excellent accuracy in corresponding to PASI\u201050 and PASI\u201075, respectively, and were more accurate than comparable changes in sPGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PASI, sPGA and LS\u2010PGA are responsive to the varying degrees of improvement in psoriasis induced by either placebo or active therapy. 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