{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:09:19Z","timestamp":1765728559099},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endogenous factors such as stress\u2010induced immune system reactivity were also associated with dyshidrosis. Herpes zoster (<jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>) incidence has been demonstrated to increase with immune deficiencies. Therefore, a relationship between dyshidrosis and <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> may exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated whether there is an association between dyshidrosis and <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population\u2010based cohort study by using Taiwan's Longitudinal Health Insurance Database (<jats:styled-content style=\"fixed-case\">LHID<\/jats:styled-content>2000) records from 1996 to 2011. The dyshidrosis group comprised 8488 patients with newly identified dyshidrosis and no history of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> prior to diagnosis of dyshidrosis. For the non\u2010dyshidrosis group, each dyshidrosis patient frequency matched according to age (5\u2010year intervals), sex and index date year with four controls selected randomly from the <jats:styled-content style=\"fixed-case\">LHID<\/jats:styled-content>2000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustments for confounding risk factors, the hazard ratio for <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> in the dyshidrosis group was 1.31 compared with the non\u2010dyshidrosis group. Regardless of comorbidities, patients with dyshidrosis had a higher risk of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> than did controls without dyshidrosis. Patients with more hospital visits that were due to dyshidrosis had a higher risk of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dyshidrosis is strongly associated with <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>. Patients treated for dyshidrosis should be warned of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13175","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T03:28:23Z","timestamp":1430191703000},"page":"2177-2183","source":"Crossref","is-referenced-by-count":10,"title":["Dyshidrosis is a risk factor for herpes zoster"],"prefix":"10.1111","volume":"29","author":[{"given":"C.\u2010Y.","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Medical Education and Research Puli Christian Hospital Puli Taiwan"},{"name":"Department of Optometry Central Taiwan University of Science and Technology Taichung Taiwan"},{"name":"Center for General Education National Taichung University of Science and Technology Taichung Taiwan"},{"name":"The General Education Center Chaoyang University of Technology Taichung Taiwan"},{"name":"Department of General Education National Chin\u2010Yi 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