{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:34:31Z","timestamp":1787164471277,"version":"build-2736575974"},"reference-count":164,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1111\/jdv.13179","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T05:18:30Z","timestamp":1441775910000},"source":"Crossref","is-referenced-by-count":29,"title":["Methods and Results Report \u2013 Evidence and consensus\u2010based (S3) Guidelines for the Treatment of Actinic Keratosis \u2013International League of Dermatological Societies in cooperation with the European Dermatology Forum"],"prefix":"10.1111","volume":"29","author":[{"given":"R.N.","family":"Werner","sequence":"first","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM) Department of Dermatology, Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM) Department of Dermatology, Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rosumeck","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM) Department of Dermatology, Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM) Department of Dermatology, Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sporbeck","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM) Department of Dermatology, Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nast","sequence":"additional","affiliation":[{"name":"Division of Evidence Based Medicine (dEBM) Department of Dermatology, Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"e_1_2_9_1_2_1","unstructured":"World Health Organization \u2013 Guidelines Review Committee.WHO handbook for guideline development.2012. URLhttp:\/\/apps.who.int\/iris\/bitstream\/10665\/75146\/1\/9789241548441_eng.pdf(last accessed: 16 January 2014)."},{"key":"e_1_2_9_1_3_1","unstructured":"AGREE Next Steps Consortium.The AGREE II Instrument.2009. URL:http:\/\/www.agreetrust.org(last accessed: 16 January 2014)."},{"key":"e_1_2_9_1_4_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration; 2011 [updated March 2011; last accessed: 5 Jan 2014]; Available from:www.cochrane-handbook.org."},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.012"},{"key":"e_1_2_9_1_8_1","unstructured":"Scottish Intercollegiate Guidelines Network.SIGN Methodology Checklist 1: Systematic Reviews and Meta\u2010analyses.2013. URLhttp:\/\/www.sign.ac.uk\/methodology\/checklists\/20121211_Checklist_for_systematic_reviews.doc(last accessed: 9 December 2013)."},{"key":"e_1_2_9_1_9_1","first-page":"CD004415","article-title":"Interventions for actinic keratoses","volume":"12","author":"Gupta AK","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_1_10_1","volume-title":"Review Manager (RevMan) [Computer program]. Version 5.2","year":"2012"},{"key":"e_1_2_9_1_11_1","volume-title":"GRADEpro. [Computer program]. Version 3.2 for Windows","author":"Brozek J","year":"2008"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.017"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.03.017"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.04.014"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.01.012"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.01.011"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.06.004"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.01.012"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.08.001"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7001.376"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.03.013"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.02.003"},{"key":"e_1_2_19_1_2_2","unstructured":"World Health Organization \u2013 Guidelines Review Committee.WHO handbook for guideline development.2012. URLhttp:\/\/apps.who.int\/iris\/bitstream\/10665\/75146\/1\/9789241548441_eng.pdf(last accessed: 16 January 2014)."},{"key":"e_1_2_19_1_3_2","unstructured":"AGREE Next Steps Consortium.The AGREE II Instrument.2009. URLhttp:\/\/www.agreetrust.org(last accessed: 16 January 2014)."},{"key":"e_1_2_19_1_4_2","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration;2011[updated March 2011; last accessed: 5 Jan 2014]; Available from:www.cochrane-handbook.org."},{"key":"e_1_2_19_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_19_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_19_1_7_2","first-page":"CD004415","article-title":"Interventions for\u00a0actinic keratoses","volume":"12","author":"Gupta AK","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_19_1_8_2","unstructured":"Scottish Intercollegiate Guidelines Network.SIGN Methodology Checklist 1: Systematic Reviews and Meta\u2010analyses.2013. URLhttp:\/\/www.sign.ac.uk\/methodology\/checklists\/20121211_Checklist_for_systematic_reviews.doc(last accessed: 9 December 2013)."},{"key":"e_1_2_19_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09040.x"},{"key":"e_1_2_19_1_10_2","first-page":"AB153","article-title":"Local skin responses associated with ingenol mebutate gel for the treatment of actinic keratosis: two analyses of pooled data","volume":"1","author":"Lebwohl M","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_19_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11103.x"},{"key":"e_1_2_19_1_12_2","unstructured":"Solaraze study 2.Solaraze gel: Diclofenac Sodium 3% \u2010 package insert."},{"key":"e_1_2_19_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10387.x"},{"key":"e_1_2_19_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00611.x"},{"key":"e_1_2_19_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08271.x"},{"issue":"12","key":"e_1_2_19_1_16_2","first-page":"1432","article-title":"A comparison of cryotherapy and imiquimod for treatment of actinic keratoses: lesion clearance, safety, and skin quality outcomes","volume":"10","author":"Foley P","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_19_1_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630310012118"},{"key":"e_1_2_19_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08488.x"},{"key":"e_1_2_19_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07470.x"},{"key":"e_1_2_19_1_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.119649"},{"key":"e_1_2_19_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.8.976"},{"key":"e_1_2_19_1_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00635.x"},{"key":"e_1_2_19_1_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04561.x"},{"key":"e_1_2_19_1_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01324.x"},{"issue":"4","key":"e_1_2_19_1_25_2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1684\/ejd.2010.1010","article-title":"Results of a randomized, placebo\u2010controlled safety and efficacy study of topical diclofenac 3% gel in organ transplant patients with multiple actinic keratoses","volume":"20","author":"Ulrich C","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_19_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03999.x"},{"key":"e_1_2_19_1_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701818870"},{"issue":"6","key":"e_1_2_19_1_28_2","first-page":"335","article-title":"Randomized trial evaluating a new 0.5% fluorouracil formulation demonstrates efficacy after 1\u2010, 2\u2010, or 4\u2010week treatment in patients with actinic keratosis","volume":"70","author":"Jorizzo J","year":"2002","journal-title":"Cutis"},{"issue":"2","key":"e_1_2_19_1_29_2","first-page":"22","article-title":"Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4\u00a0weeks","volume":"70","author":"Weiss J","year":"2002","journal-title":"Cutis"},{"key":"e_1_2_19_1_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.7.813"},{"key":"e_1_2_19_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)80012-1"},{"issue":"6","key":"e_1_2_19_1_32_2","first-page":"629","article-title":"Short incubation PDT versus 5\u2010FU in treating actinic keratoses","volume":"2","author":"Smith S","year":"2003","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_19_1_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12343"},{"issue":"2","key":"e_1_2_19_1_34_2","first-page":"144","article-title":"Comparison of 5% 5\u2010fluorouracil cream and 5% imiquimod cream in the management of actinic keratoses on the face and scalp","volume":"6","author":"Tanghetti E","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_19_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.07.004"},{"key":"e_1_2_19_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07942.x"},{"key":"e_1_2_19_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09260.x"},{"key":"e_1_2_19_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.01.047"},{"key":"e_1_2_19_1_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.4.467"},{"key":"e_1_2_19_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.010"},{"key":"e_1_2_19_1_41_2","unstructured":"NCT00828568.A Therapeutic Equivalence Study of Two Imiquimod Cream 5% Treatments for Patients With Actinic Keratosis."},{"key":"e_1_2_19_1_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06932.x"},{"key":"e_1_2_19_1_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01047.x"},{"key":"e_1_2_19_1_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1498"},{"key":"e_1_2_19_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.02.022"},{"key":"e_1_2_19_1_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08269.x"},{"key":"e_1_2_19_1_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03259.x"},{"key":"e_1_2_19_1_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10098.x"},{"key":"e_1_2_19_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.933"},{"key":"e_1_2_19_1_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111170"},{"key":"e_1_2_19_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.008"},{"key":"e_1_2_19_1_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10613.x"},{"key":"e_1_2_19_1_53_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.1.41"},{"issue":"12","key":"e_1_2_19_1_54_2","first-page":"1483","article-title":"A multicenter, randomized, vehicle\u2010controlled phase 2 study of blue light photodynamic therapy with aminolevulinic acid HCl 20% topical solution for the treatment of actinic keratoses on the upper extremities: the effect of occlusion during the drug incubation period","volume":"11","author":"Schmieder GJ","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_19_1_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09873.x"},{"issue":"9","key":"e_1_2_19_1_56_2","first-page":"1049","article-title":"A randomized, blinded, bilateral intraindividual, vehicle\u2010controlled trial of the use of photodynamic therapy with 5\u2010aminolevulinic acid and blue light for the treatment of actinic keratoses of the upper extremities","volume":"10","author":"Taub AF","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_19_1_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07946.x"},{"key":"e_1_2_19_1_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700098"},{"key":"e_1_2_19_1_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01384.x"},{"key":"e_1_2_19_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.031"},{"key":"e_1_2_19_1_61_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.49"},{"key":"e_1_2_19_1_62_2","unstructured":"Photocure\u2010Australian.Metvixia cream 16.8%.2004."},{"key":"e_1_2_19_1_63_2","unstructured":"Photocure\u2010US.Metvixia cream 16.8%.2004."},{"key":"e_1_2_19_1_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01096.x"},{"key":"e_1_2_19_1_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06054.x"},{"key":"e_1_2_19_1_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/jep.12159"},{"key":"e_1_2_19_1_67_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701487635"},{"key":"e_1_2_19_1_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12036"},{"key":"e_1_2_19_1_69_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.27749"},{"key":"e_1_2_19_1_70_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2009.2733"},{"key":"e_1_2_19_1_71_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.123492"},{"key":"e_1_2_19_1_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2008.00497.x"},{"key":"e_1_2_19_1_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.483"},{"key":"e_1_2_19_1_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10833.x"},{"key":"e_1_2_19_1_75_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2003.00003.x"},{"key":"e_1_2_19_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.020"},{"key":"e_1_2_19_1_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1997.tb01693.x"},{"key":"e_1_2_19_1_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20379"},{"key":"e_1_2_19_1_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.08.039"},{"key":"e_1_2_19_1_80_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630152696314"},{"issue":"12","key":"e_1_2_19_1_81_2","first-page":"1281","article-title":"Chemoprevention of human actinic keratoses by topical 2\u2010(difluoromethyl)\u2010dl\u2010ornithine","volume":"9","author":"Alberts DS","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_19_1_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70054-0"},{"key":"e_1_2_19_1_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00595.x"},{"issue":"1","key":"e_1_2_19_1_84_2","first-page":"4","article-title":"Comparison of the efficacy of cryotherapy and 0.1% Acnalen gel vs. cryotherapy and placebo in the treatment of actinic keratoses","volume":"28","author":"Azimi H","year":"2012","journal-title":"Pak J Med Sci"},{"key":"e_1_2_19_1_85_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb05876.x"},{"key":"e_1_2_19_1_86_2","first-page":"308","article-title":"Nicotinamide for skin cancer chemoprevention","volume":"8","author":"Chen AC","year":"2012","journal-title":"Asia\u2010Pacific J Clin Oncol"},{"key":"e_1_2_19_1_87_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000300003"},{"key":"e_1_2_19_1_88_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0210"},{"issue":"10","key":"e_1_2_19_1_89_2","first-page":"1124","article-title":"Effect of retinoid pretreatment on outcomes of patients treated by photodynamic therapy for actinic keratosis of the hand and forearm","volume":"10","author":"Galitzer BI","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_19_1_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00770.x"},{"key":"e_1_2_19_1_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01102.x"},{"key":"e_1_2_19_1_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06865_supp.x"},{"issue":"2","key":"e_1_2_19_1_93_2","first-page":"133","article-title":"One\u2010week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double\u2010blind, vehicle\u2010controlled, long\u2010term study","volume":"5","author":"Jorizzo J","year":"2006","journal-title":"J Drugs Dermatol"},{"issue":"9","key":"e_1_2_19_1_94_2","first-page":"1101","article-title":"A randomized, double\u2010blinded, placebo\u2010controlled, multicenter, efficacy and safety study of 3.75% imiquimod cream following cryosurgery for the treatment of actinic keratoses","volume":"9","author":"Jorizzo JL","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_19_1_95_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.451"},{"key":"e_1_2_19_1_96_2","first-page":"161","article-title":"Comparative Evaluation of the efficacy and Safety of Masoprocol and 5\u2010Fluorouracil Cream for the Treatment of Multiple Actinic Keratoses of the Head and Neck","volume":"1","author":"Kulp\u2010Shorten C","year":"1993","journal-title":"Journal of Geriatric Dermatology"},{"key":"e_1_2_19_1_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70070-I"},{"key":"e_1_2_19_1_98_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09659.x"},{"key":"e_1_2_19_1_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91393-9"},{"key":"e_1_2_19_1_100_2","unstructured":"NCT00774787.Topical imiquimod cream in combination with cryotherapy for the treatment of actinic keratoses."},{"key":"e_1_2_19_1_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70113-G"},{"key":"e_1_2_19_1_102_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04005.x"},{"issue":"5","key":"e_1_2_19_1_103_2","first-page":"451","article-title":"Can topical calcipotriol be a treatment alternative in actinic keratoses? A preliminary report","volume":"8","author":"Seckin D","year":"2009","journal-title":"J Drugs Dermatol"},{"issue":"1","key":"e_1_2_19_1_104_2","first-page":"35","article-title":"Treatment of actinic keratoses with sequential use of photodynamic therapy; and imiquimod 5% cream","volume":"8","author":"Shaffelburg M","year":"2009","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_19_1_105_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04003.x"},{"key":"e_1_2_19_1_106_2","first-page":"5","article-title":"Nicotinamide for skin cancer prevention","volume":"53","author":"Surjana D","year":"2012","journal-title":"Aust J Dermatol"},{"key":"e_1_2_19_1_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.459"},{"key":"e_1_2_19_1_108_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08615.x"},{"key":"e_1_2_19_1_109_2","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2007.00033"},{"key":"e_1_2_19_1_110_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510032887"},{"key":"e_1_2_19_1_111_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310143291602"},{"key":"e_1_2_19_1_112_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10893.x"},{"key":"e_1_2_19_1_113_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1996.tb01031.x"},{"key":"e_1_2_19_1_114_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09817.x"},{"key":"e_1_2_19_1_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10209.x"},{"key":"e_1_2_19_1_116_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09119.x"},{"key":"e_1_2_19_1_117_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08450.x"},{"issue":"4","key":"e_1_2_19_1_118_2","first-page":"AB177","article-title":"Temperature\u2010modulated photodynamic therapy for the treatment of actinic keratoses on the extremities","volume":"66","author":"Willey A","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_19_1_119_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02340.x"},{"key":"e_1_2_19_1_120_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114288"},{"issue":"2","key":"e_1_2_19_1_121_2","first-page":"S99","article-title":"Oral nicotinamide for skin cancer prevention. 41st Annual Meeting of the European Society for Dermatological Research, ESDR 2011 Barcelona Spain","volume":"131","author":"Damian D","year":"2011","journal-title":"J Invest Dermatol"},{"key":"e_1_2_19_1_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2011.03.257"},{"key":"e_1_2_19_1_123_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630902882048"},{"key":"e_1_2_19_1_124_2","first-page":"65","article-title":"Celecoxib may be effective in preventing non\u2010melanoma skin cancers","volume":"7","year":"2011","journal-title":"Int J Cancer Res"},{"key":"e_1_2_19_1_125_2","first-page":"35","article-title":"Ingenol mebutate (Picato) for actinic keratoses","volume":"54","year":"2012","journal-title":"Med Letter Drugs Therap"},{"issue":"4","key":"e_1_2_19_1_126_2","first-page":"AB159","article-title":"Two\u2010day topical treatment with ingenol mebutate gel, 0.05% for actinic keratoses on the trunk and extremities: analysis of data pooled from two trials","volume":"66","author":"Anderson L","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_19_1_127_2","first-page":"AB3","article-title":"Three\u2010day topical treatment with ingenol mebutate gel, 0.015% for actinic keratoses on the face and scalp: analysis of data pooled from two trials","volume":"1","author":"Berman B","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_19_1_128_2","first-page":"196","article-title":"Efficacy and safety comparison of photodynamic therapy with BF\u2010200 ALA versus Metvix for the treatment of actinic keratosis: a prospective, randomized, placebo\u2010controlled multinational, phase III study","volume":"9","author":"Dirschka T","year":"2011","journal-title":"J German Soc Dermatol"},{"key":"e_1_2_19_1_129_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10737.x"},{"issue":"5","key":"e_1_2_19_1_130_2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1001\/archdermatol.2011.2273","article-title":"Chemoprevention for keratinocytic (pre)cancers: balancing the risks and benefits","volume":"148","author":"Hollestein LM","year":"2012","journal-title":"Arch Dermatol"},{"key":"e_1_2_19_1_131_2","doi-asserted-by":"publisher","DOI":"10.2165\/11470090-000000000-00000"},{"issue":"2","key":"e_1_2_19_1_132_2","first-page":"AB2","article-title":"Cryosurgery followed by imiquimod 3.75% to treat actinic keratosis","volume":"66","author":"Lee J","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_19_1_133_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02108.x"},{"key":"e_1_2_19_1_134_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.cmr.0000399528.54849.b6"},{"issue":"2","key":"e_1_2_19_1_135_2","first-page":"461","article-title":"Erratum: Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: A randomized clinical trial (British Journal of Dermatology (2012) 166 (1262\u20109))","volume":"167","author":"Togsverd\u2010Bo K","year":"2012","journal-title":"Brit J Dermatol"},{"key":"e_1_2_19_1_136_2","first-page":"957","article-title":"Temperature modulated photodynamic therapy for the treatment of actinic keratoses on the extremities","volume":"43","author":"Willey A","year":"2011","journal-title":"Lasers Surg Med"},{"key":"e_1_2_19_1_137_2","first-page":"8","article-title":"Temperature modulated photodynamic therapy for the treatment of actinic keratoses on the extremities","volume":"44","author":"Willey A","year":"2012","journal-title":"Lasers Surg Med"},{"issue":"4","key":"e_1_2_19_1_138_2","first-page":"AB175","article-title":"Efficacy of\u00a0photodynamic therapy associated to pretreatment with AHA peel\u00a0in facial diffuse photodamage","volume":"66","author":"Almagro BM","year":"2012","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"e_1_2_19_1_139_2","first-page":"53","article-title":"Safety and efficacy comparison of blue versus red light sources for photodynamic therapy using methyl aminolevulinate in photodamaged skin","volume":"10","author":"Palm MD","year":"2011","journal-title":"J Drugs Dermatol"},{"issue":"3","key":"e_1_2_19_1_140_2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1684\/ejd.2012.1707","article-title":"Recurrence rates and patient assessed outcomes of 0.5% 5\u2010fluorouracil in combination with salicylic acid treating actinic keratoses","volume":"22","author":"Stockfleth E","year":"2012","journal-title":"Euro J Dermatol"},{"key":"e_1_2_19_1_141_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07616.x"},{"issue":"3","key":"e_1_2_19_1_142_2","article-title":"Multicenter, randomized, parallel\u2010group, double\u2010blind, vehicle\u2010controlled study to evaluate the efficacy and safety of PEP005 (ingenol mebutate) gel, 0.05% in patients with actinic keratoses on nonhead locations","volume":"62","author":"Swanson N","year":"2010","journal-title":"J Am Acad Dermatol"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13179","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:45:21Z","timestamp":1695545121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,9]]},"references-count":164,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/jdv.13179"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13179","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,9]]}}}