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Adult female acne may persist from adolescence or may have its first occurrence once adulthood has been reached. The clinical presentation and pathogenesis of adult female acne may be somewhat different to that of adolescent acne and this may require a different treatment approach. Genetic and hormonal factors are thought to play key roles in the pathogenesis of adult female acne and the disease is characterized by a chronic evolution with frequent relapses requiring long\u2010term maintenance therapy. Fixed\u2010dose retinoid\/antimicrobial combinations may be of interest for the treatment of adult female acne given that subgroup analysis of clinical trials has indicated that they are effective against both inflammatory and non\u2010inflammatory lesions in these patients. These treatments may also be of interest, given the chronic course of the disease in adult females, the high likelihood of the presence of antibiotic\u2010resistant <jats:italic>P.\u00a0acnes<\/jats:italic> and the poor adherence of patients to other long\u2010term therapies. Oral hormonal treatment or isotretinoin may be required in patients with severe acne or disease that is refractory to other treatments. Additional clinical studies of acne treatments specifically conducted in adult female patients are required to increase the evidence base on which future treatment recommendations can be based.<\/jats:p>","DOI":"10.1111\/jdv.13188","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T01:34:56Z","timestamp":1433986496000},"page":"14-19","source":"Crossref","is-referenced-by-count":50,"title":["Treatment of adult female acne: a new challenge"],"prefix":"10.1111","volume":"29","author":[{"given":"B.","family":"Dr\u00e9no","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Cancerology University of Nantes Nantes 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