{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:10:25Z","timestamp":1785546625527,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Galderma Laboratorium GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In addition to physical long\u2010lasting effects such as permanent scarring and disfigurement, acne has acute and long\u2010term psychosocial effects that affect the individual's quality of life. As with other chronic diseases, treatment success is often compromised by poor adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Two main objectives of this non\u2010interventional study were to assess the long\u2010term effect of the fixed\u2010dose combination adapalene 0.1%\/benzoyl peroxide 2.5% (adapalene\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> gel) on quality of life and treatment adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with moderate to severe facial acne receiving adapalene\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> alone or in combination with other drugs were enrolled in this non\u2010interventional study. Data were documented at baseline and after 3 and 9\u00a0months of adapalene\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> treatment. The secondary outcomes reported here include quality of life determined by the Cardiff Acne Disability Index (<jats:styled-content style=\"fixed-case\">CADI<\/jats:styled-content>), treatment adherence assessed by the <jats:styled-content style=\"fixed-case\">ECOB<\/jats:styled-content> (Elaboration d'un outil d'evaluation de l'observance des traitements medicamenteux) questionnaire, and patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 5131 patients were included in the efficacy evaluation. After 9\u00a0months, mean (\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) quality of life (<jats:styled-content style=\"fixed-case\">CADI<\/jats:styled-content>) improved significantly from 5.9\u00a0\u00b1\u00a03.0 to 2.4\u00a0\u00b1\u00a02.7 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Patients with more severe acne at baseline tended to achieve a greater improvement in quality of life. Long\u2010term adherence was found to be good in 83.9% of patients. Adherence had a significant effect on efficacy and quality of life (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001 respectively). The vast majority of patients (92.1%) reported subjective improvement at the interim analysis. Accordingly, most patients (84.8%) were satisfied or very satisfied with adapalene\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> by the end of the observation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical improvement of the disease led to an increase in quality of life among acne patients. The treatment success may be a motivation factor for patients to stay adherent over the long\u2010term treatment course, indicating the qualification of adapalene\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> topical gel as an appropriate medication also in the long\u2010term usage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13195","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T01:34:58Z","timestamp":1433986498000},"page":"23-29","source":"Crossref","is-referenced-by-count":14,"title":["Effect of adapalene 0.1%\/benzoyl peroxide 2.5% topical gel on quality of life and treatment adherence during long\u2010term application in patients with predominantly moderate acne with or without concomitant medication \u2013 additional results from the non\u2010interventional cohort study 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