{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:16:33Z","timestamp":1791180993452,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T00:00:00Z","timestamp":1439510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Actinic Keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>) is the clinical manifestation of cutaneous dysplasia of epidermal keratinocytes, with progressive trend towards squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the strength of the correlation between keratinocyte atypia, as detected by Reflectance Confocal Microscopy (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>) and histopathology, and to develop a more objective atypia grading scale for <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> quantification, through a discrete ranking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 48 <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s and two control areas (photodamaged and non\u2010photodamaged skin) were selected for this study. All these areas were documented by <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> and biopsied for histopathology. One representative image of the epidermis was selected for <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> and for histopathology and used for side\u2010by\u2010side comparison with purpose written software. The assessor chose which of two images displayed more keratinocyte atypia, and an ordered list from the image showing the least to the most keratinocyte atypia was generated. Three evaluations were obtained for <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> and two for histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Good interobserver correlation was obtained for <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> and histopathology grading, with high concordance between <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> and histopathology grading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Expert rater scan consistently distinguish different grades of cytological atypia. Non\u2010invasive <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> data from <jats:italic>in\u00a0vivo<\/jats:italic> imaging can be graded for keratinocyte atypia, comparable to histopathological grading.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13215","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T13:02:52Z","timestamp":1439557372000},"page":"2216-2221","source":"Crossref","is-referenced-by-count":53,"title":["Grading keratinocyte atypia in actinic keratosis: a correlation of reflectance confocal microscopy and histopathology"],"prefix":"10.1111","volume":"29","author":[{"given":"G.","family":"Pellacani","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Dermatologie am Regierungsviertel Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Casari","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.W.","family":"Prow","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre School of Medicine Translational Research Institute The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cannillo","sequence":"additional","affiliation":[{"name":"Karmaweb S.r.l. 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