{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:58:36Z","timestamp":1792699116429,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glycerol is known to possess anti\u2010irritant and hydrating properties and previous studies suggested that xylitol may also have similar effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Our aim was to study whether different concentrations of these polyols restore skin barrier function and soothe inflammation in sodium lauryl sulphate (\n                      <jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>\n                      )\u2010induced acute irritation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The experiments were performed on male\n                      <jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>\n                      \u20101 hairless mice. The skin of the dorsal region was exposed to\n                      <jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>\n                      (5%) for 3\u00a0h alone or together with 5% or 10% of glycerol respectively. Further two groups received xylitol solutions (8.26% and 16.52% respectively) using the same osmolarities, which were equivalent to those of the glycerol treatments. The control group was treated with purified water. Transepidermal water loss (\n                      <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>\n                      ) and skin hydration were determined. Microcirculatory parameters of inflammation were observed by means of intravital videomicroscopy (\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      ). Furthermore, accumulation of neutrophil granulocytes and lymphocytes, the expression of inflammatory cytokines and\n                      <jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>\n                      penetration were assessed, as well.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment with the 10% of glycerol and both concentrations of xylitol inhibited the\n                      <jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>\n                      \u2010induced elevation of\n                      <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>\n                      and moderated the irritant\u2010induced increase in dermal blood flow and in the number of leucocyte\u2010endothelial interactions. All concentrations of the applied polyols improved hydration and prevented the accumulation of lymphocytes near the treatment site. At the\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      level, neither glycerol nor xylitol influenced the expression of interleukin\u20101 alpha. However, expression of interleukin\u20101 beta was significantly decreased by the 10% glycerol treatment, while expression of tumour necrosis factor\u2010alpha decreased upon the same treatment, as well as in response to xylitol. Higher polyol treatments decreased the\n                      <jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>\n                      penetration to the deeper layers of the stratum corneum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both of the analysed polyols exert considerable anti\u2010irritant and anti\u2010inflammatory properties, but the effective concentration of xylitol is lower than that of glycerol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.13225","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:33:31Z","timestamp":1442277211000},"page":"2333-2341","source":"Crossref","is-referenced-by-count":38,"title":["Anti\u2010irritant and anti\u2010inflammatory effects of glycerol and xylitol in sodium lauryl sulphate\u2010induced acute 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