{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T16:00:00Z","timestamp":1791734400520,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Galderma R&D"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Unmet needs exist in actinic keratosis (\n AK<\/jats:styled-content>\n ) treatment. Daylight photodynamic therapy (\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n ) has shown good efficacy and safety results compared to conventional\n PDT<\/jats:styled-content>\n (c\u2010\n PDT<\/jats:styled-content>\n ) in a recent Phase\n III<\/jats:styled-content>\n multi\u2010centre randomised controlled trial in Australia among 100 subjects with\n AK<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n Demonstrate non\u2010inferior efficacy and superior safety of\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n compared to c\u2010\n PDT<\/jats:styled-content>\n in treating multiple mild and\/or moderate facial\/scalp\n AK<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Phase\n III<\/jats:styled-content>\n , 12 week, multi\u2010centre, randomised, investigator\u2010blinded, controlled, intra\u2010individual study conducted at different latitudes in Europe.\n AK<\/jats:styled-content>\n s of adult subjects were treated once with methyl aminolevulinate (\n MAL<\/jats:styled-content>\n )\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n on one side of the face and\n MAL<\/jats:styled-content>\n c\u2010\n PDT<\/jats:styled-content>\n contralaterally. Endpoints for\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n concerned efficacy (non\u2010inferiority regarding complete lesion response at week 12) and safety (superiority regarding subject's assessment of pain after treatment, on an 11\u2010point numeric rating scale). Safety evaluation also included incidence of adverse events. Subject satisfaction was described using a questionnaire at baseline and last visit.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At week 12, the total lesion complete response rate with\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n was similar (non\u2010inferior) to c\u2010\n PDT<\/jats:styled-content>\n (70% vs. 74%, respectively; 95%\n CI<\/jats:styled-content>\n [\u22129.5; 2.4] in\n PP<\/jats:styled-content>\n analysis, confirmed in\n ITT<\/jats:styled-content>\n analysis). In addition, efficacy of\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n was demonstrated regardless of weather conditions (sunny or cloudy).\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n was nearly painless compared to c\u2010\n PDT<\/jats:styled-content>\n (0.7 vs. 4.4, respectively;\n P<\/jats:italic>\n < 0.001), better tolerated and resulted in higher subject satisfaction.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n in comparison with c\u2010\n PDT<\/jats:styled-content>\n was as effective, better tolerated and nearly painless with high patient satisfaction, and may be considered a treatment of choice to meet needs of patients with mild or moderate facial\/scalp\n AK<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.13228","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T07:22:55Z","timestamp":1444029775000},"page":"2342-2348","source":"Crossref","is-referenced-by-count":131,"title":["Daylight photodynamic therapy with methyl aminolevulinate cream is effective and nearly painless in treating actinic keratoses: a randomised, investigator\u2010blinded, controlled, phase\n III<\/scp>\n study throughout Europe"],"prefix":"10.1111","volume":"29","author":[{"given":"J\u2010P.","family":"Lacour","sequence":"first","affiliation":[{"name":"Department of Dermatology H\u00f4pital Archet2, University Hospital of Nice Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Campus Mitte Universit\u00e4tsmedizin Berlin Klinik f\u00fcr Dermatologie Venerologie und Allergologie Hautturmorcentrum der Charit\u00e9 (HTCC) Berlin 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