{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:11:24Z","timestamp":1777047084817,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Extracorporeal photopheresis (ECP<\/jats:styled-content>) is recommended for the erythrodermic mycosis fungoides (MF<\/jats:styled-content>) and Sezary syndrome (SS<\/jats:styled-content>) alone or in combination with other therapies. The possibility of a differential response in the blood and skin has hardly been addressed in the literature.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To evaluate the clinical response rate of patients with erythrodermic MF<\/jats:styled-content> and SS<\/jats:styled-content> to ECP<\/jats:styled-content> as part of a multimodality approach and to compare the kinetics of the blood and skin responses in the presence of leukaemic involvement.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty patients were treated with ECP<\/jats:styled-content> and other modalities at a tertiary medical centre in 2003\u20132013. Ten patients had SS<\/jats:styled-content>, 1 CD<\/jats:styled-content>8\u2010positive patch\u2010stage MF<\/jats:styled-content> with leukaemic involvement and nine erythrodermic MF<\/jats:styled-content>. Clinical and outcome data were collected retrospectively from the medical files. Response was evaluated overall and for blood and skin separately.<\/jats:p><\/jats:sec>Results<\/jats:title>Adjunctive therapies were interferon\u2010\u03b1, narrow\u2010band ultraviolet B, psoralen and ultraviolet A, isotretinoin, acitretin, methotrexate, prednisone, topical nitrogen mustard and total skin or localized hands\/feet electron beam radiotherapy. Overall response was documented in 13 patients (65%) \u2013 complete 30%, partial 35% \u2013 and maintained for >2\u00a0years in 38.5%. In patients with leukaemic involvement (n<\/jats:italic>\u00a0=\u00a011), the blood response occurred earlier than skin response (P<\/jats:italic>\u00a0=\u00a00.008) and was maintained longer (P<\/jats:italic>\u00a0=\u00a00.03). In three of the patients with a complete blood response, the skin response was partial (n<\/jats:italic>\u00a0=\u00a02) or absent (n<\/jats:italic>\u00a0=\u00a01).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Extracorporeal photopheresis as part of a multimodality approach yields a high durable clinical response in patients with erythrodremic MF<\/jats:styled-content> and SS<\/jats:styled-content>. The kinetics of the response differ between the blood and skin. The blood response occurs earlier and lasts longer; it does not necessarily predict the clinical skin response. Further studies are needed to determine if there is a survival advantage to a blood response in the absence of a skin response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13243","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T15:17:58Z","timestamp":1440429478000},"page":"2382-2389","source":"Crossref","is-referenced-by-count":9,"title":["Erythrodermic mycosis fungoides and S\u00e9zary syndrome treated with extracorporeal photopheresis as part of a multimodality regimen: A single\u2010centre experience"],"prefix":"10.1111","volume":"29","author":[{"given":"L.","family":"Atzmony","sequence":"first","affiliation":[{"name":"Department of Dermatology Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Amitay\u2010Laish","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rabin Medical Center Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gurion","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Hematology Institute Davidoff Cancer Center Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Shahal\u2010Zimra","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hodak","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rabin Medical Center Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118538"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198702053160603"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08415.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12121"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90241-4"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12311"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.232"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12571"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12175"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2006.n.063"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1054"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371732"},{"key":"e_1_2_5_16_1","first-page":"629","article-title":"Photopheresis therapy of cutaneous T\u2010cell lymphoma: the Yale\u2010New Haven Hospital experience","volume":"62","author":"Heald PW","year":"1989","journal-title":"Yale J Biol Med"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2003.01646.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:04:19Z","timestamp":1695542659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,24]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/jdv.13243"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13243","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,24]]}}}