{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:52:05Z","timestamp":1784137925401,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\u2010inhibitor vemurafenib, used in patients with metastatic melanoma, induces multiple cutaneous side\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this work was to evaluate the development of palmoplantar fibromatosis in a population of patients treated with the <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content> inhibitor vemurafenib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between April 2011 and February 2013, we initiated a treatment with vemurafenib in 53 patients with an unresectable stage <jats:styled-content style=\"fixed-case\">IIIC<\/jats:styled-content> or stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> melanoma. The patients were followed\u2010up on a regular base to monitor possible side\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A plantar or palmar fibromatosis was observed in five of 53 patients treated with vemurafenib. In four of these patients other risk factors for the development of palmoplantar fibromatosis were absent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\u2010inhibitor vemurafenib might induce palmoplantar fibromatosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13268","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T03:08:33Z","timestamp":1440472113000},"page":"1133-1135","source":"Crossref","is-referenced-by-count":6,"title":["Vemurafenib\u2010associated <scp>D<\/scp>upuytren\u2010 and Ledderhose palmoplantar fibromatosis in metastatic melanoma patients"],"prefix":"10.1111","volume":"30","author":[{"given":"V.","family":"Vandersleyen","sequence":"first","affiliation":[{"name":"Department of Dermatology Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB) Laarbeeklaan 101 Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Grosber","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB) Laarbeeklaan 101 Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wilgenhof","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB) Laarbeeklaan 101, Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"De Kock","sequence":"additional","affiliation":[{"name":"Department of <i>In Vitro<\/i> Toxicology and Dermato\u2010Cosmetology Center for Pharmaceutical Research Vrije Universiteit Brussel Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Neyns","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB) Laarbeeklaan 101, Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gutermuth","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB) Laarbeeklaan 101 Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"326","article-title":"Genetic susceptibility to Dupuytren's disease: transforming growth factor beta receptor (TGFbetaR) gene polymorphisms and Dupuytren's disease","volume":"56","author":"Beyat A","year":"2003","journal-title":"Br J Plast Surg"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101029"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000060531.98180.32"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.12.009"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-007-9071-1"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1111636"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13268","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.13268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T13:48:47Z","timestamp":1693921727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,24]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/jdv.13268"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13268","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,24]]}}}