{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:47:19Z","timestamp":1791388039658,"version":"4.3.3"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Classification of hand eczema (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>) is mandatory in epidemiological and clinical studies, and also important in clinical work.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim was to test a recently proposed classification system of HE in clinical practice in a prospective multicentre study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were recruited from nine different tertiary referral centres. All patients underwent examination by specialists in dermatology and were checked using relevant allergy testing. Patients were classified into one of the six diagnostic subgroups of <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>: allergic contact dermatitis, irritant contact dermatitis, atopic <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>, protein contact dermatitis\/contact urticaria, hyperkeratotic endogenous eczema and vesicular endogenous eczema, respectively. An additional diagnosis was given if symptoms indicated that factors additional to the main diagnosis were of importance for the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and twenty\u2010seven patients were included, 379 (89%) of the patients could be classified directly into one of the six diagnostic subgroups, with irritant and allergic contact dermatitis comprising 249 patients (58%). For 32 (7%) more than one of the six diagnostic subgroups had been formulated as a main diagnosis, and 16 (4%) could not be classified. 38% had one additional diagnosis and 26% had two or more additional diagnoses. Eczema on feet was found in 30% of the patients, statistically significantly more frequently associated with hyperkeratotic and vesicular endogenous eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We find that the classification system investigated in the present study was useful, being able to give an appropriate main diagnosis for 89% of HE patients, and for another 7% when using two main diagnoses. The fact that more than half of the patients had one or more additional diagnoses illustrates that <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content> is a multifactorial disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13308","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T05:57:21Z","timestamp":1442296641000},"page":"2417-2422","source":"Crossref","is-referenced-by-count":90,"title":["Classification of hand eczema"],"prefix":"10.1111","volume":"29","author":[{"given":"T.","family":"Agner","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Aalto\u2010Korte","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Foti","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Department of Biomedical Science and Human Oncology University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gimen\u00e9z\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Institut Mar d\u2032Investigations Mediques Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Goncalo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital and Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital K. 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Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Le Coz","sequence":"additional","affiliation":[{"name":"Cabinet de Dermatologie and Laboratoire de Dermatochimie Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.L.","family":"Diepgen","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Occupational and Environmental Dermatology University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the European Environmental and Contact Dermatitis Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7822"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2010.09094"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08907.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01911.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.04001.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1985.tb01130.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00338.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01915.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-925.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2011.10122"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12510_1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.3.305"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1484"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02863.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12324"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310007184"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:03:48Z","timestamp":1695542628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,15]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/jdv.13308"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13308","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,15]]}}}