{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:09:32Z","timestamp":1785186572628,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Johnson & Johnson Consumer & Personal Products Worldwide"},{"name":"A Division of Johnson & Johnson Consumer Companies, Inc., USA."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical minoxidil formulations have been shown to be effective in treating androgenetic alopecia (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>) for 12\u00a0months. Efficacy and safety in both frontotemporal and vertex regions over longer application periods have not been studied so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of 5% minoxidil topical foam (5% <jats:styled-content style=\"fixed-case\">MTF<\/jats:styled-content>) in the frontotemporal and vertex areas in patients with moderate <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> over 104\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An 80\u2010week, open\u2010label extension phase was performed, following a 24\u2010week randomized, double\u2010blind, placebo\u2010controlled study in men with <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content><jats:sub>vertex<\/jats:sub> to <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>. Group 1 (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) received ongoing 5% <jats:styled-content style=\"fixed-case\">MTF<\/jats:styled-content> for 104\u00a0weeks, Group 2 (<jats:italic>n<\/jats:italic>\u00a0=\u00a023) received placebo topical foam (pla<jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content>) until week 24, followed by 5% <jats:styled-content style=\"fixed-case\">MTF<\/jats:styled-content> until week 104 during the extension phase. Frontotemporal and vertex target area non\u2010vellus hair counts (f\u2010<jats:styled-content style=\"fixed-case\">TAHC<\/jats:styled-content>, v\u2010<jats:styled-content style=\"fixed-case\">TAHC<\/jats:styled-content>) and cumulative hair width (f\u2010<jats:styled-content style=\"fixed-case\">TAHW<\/jats:styled-content>, v\u2010<jats:styled-content style=\"fixed-case\">TAHW<\/jats:styled-content>) were assessed at baseline and at weeks 24, 52, 76 and 104.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Group 1, f\u2010<jats:styled-content style=\"fixed-case\">TAHW<\/jats:styled-content> and f\u2010<jats:styled-content style=\"fixed-case\">TAHC<\/jats:styled-content> showed a statistically significant increase from baseline to week 52 and week 76, respectively, returning to values comparable to baseline at week 104. No significant differences were found between baseline and week 104 in v\u2010<jats:styled-content style=\"fixed-case\">TAHC<\/jats:styled-content> in Group 1 as well as f\u2010<jats:styled-content style=\"fixed-case\">TAHC<\/jats:styled-content>, v\u2010<jats:styled-content style=\"fixed-case\">TAHC<\/jats:styled-content>, f\u2010<jats:styled-content style=\"fixed-case\">TAHW<\/jats:styled-content> and v\u2010<jats:styled-content style=\"fixed-case\">TAHW<\/jats:styled-content> values in Group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>5% <jats:styled-content style=\"fixed-case\">MTF<\/jats:styled-content> is effective in stabilizing hair density, hair width and scalp coverage in both frontotemporal and vertex areas over an application period of 104\u00a0weeks, while showing a good safety and tolerability profile with a low rate of irritant contact dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13324","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T12:01:35Z","timestamp":1442836895000},"page":"1183-1189","source":"Crossref","is-referenced-by-count":33,"title":["Effect of minoxidil topical foam on frontotemporal and vertex androgenetic alopecia in men: a 104\u2010week open\u2010label clinical trial"],"prefix":"10.1111","volume":"30","author":[{"given":"V.","family":"Kanti","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Clinical Research Center for Hair and Skin Science Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hillmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Clinical Research Center for Hair and Skin Science Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kottner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Clinical Research Center for Hair and Skin Science Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stroux","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Clinical Research Center for Hair and Skin Science Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Department of Biometrics and Clinical Epidemiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Canfield","sequence":"additional","affiliation":[{"name":"Canfield Scientific, Inc. Fairfield NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Blume\u2010Peytavi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Clinical Research Center for Hair and Skin Science Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0379.2011.07802.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.3.311"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.724"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000248902"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70006-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124088"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000248903"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079595"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13399"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375320"},{"key":"e_1_2_6_13_1","unstructured":"ClinicalTrials.gov National Library of Medicine (US).Identifier NCT01319370 Effectiveness and Safety of Minoxidil Foam vs. Placebo Foam for Androgenetic Alopecia; 2011 March 18. 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