{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:47:18Z","timestamp":1768283238467,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Alopecia areata (AA<\/jats:styled-content>) is a T\u2010cell\u2010driven autoimmune disease of the hair follicle and frequently reported to be associated with inflammatory skin diseases (ISD<\/jats:styled-content>) such as atopic eczema (AE<\/jats:styled-content>) or psoriasis. Interestingly, AA<\/jats:styled-content> on the one hand and both AE<\/jats:styled-content> and psoriasis on the other hand are believed to be driven by mutually antagonistic T\u2010cell subsets.<\/jats:p><\/jats:sec>Objective<\/jats:title>To characterize AA<\/jats:styled-content>\u2010specific T\u2010cell profiles and inflammatory pattern by intra\u2010individual comparison of AA<\/jats:styled-content> and coexistent ISD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>112 patients with AA<\/jats:styled-content> were recruited and investigated for coexisting ISD<\/jats:styled-content>. In\u2010depth analyses were performed in patients with AA<\/jats:styled-content> and AE<\/jats:styled-content> (n<\/jats:italic> = 2), AA<\/jats:styled-content> and psoriasis (n<\/jats:italic> = 1), AA<\/jats:styled-content> and psoriasis and AE<\/jats:styled-content> (n<\/jats:italic> = 1) and AA<\/jats:styled-content> and lichen planus (n<\/jats:italic> = 1), using histology, immunohistochemistry and cytokine staining of T cells isolated from lesional skin.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 112 AA<\/jats:styled-content> patients investigated, 23 suffered from an ISD<\/jats:styled-content>. The prevalence of AE<\/jats:styled-content>, vitiligo, psoriasis and lichen planus was higher in the investigated AA<\/jats:styled-content> cohort than in the normal population. The clinical as well as histological phenotype of AA<\/jats:styled-content> the coexistent ISD<\/jats:styled-content> were unequivocal. In line with this, T\u2010cell infiltrates were found to be disease\u2010characteristics with AA<\/jats:styled-content> and lichen planus dominated by CD<\/jats:styled-content>8+ and IFN<\/jats:styled-content>\u2010\u03b3+ TNF<\/jats:styled-content>\u2010\u03b1+ producing T cells while psoriasis lesions in the same patients were dominated by IL<\/jats:styled-content>\u201017+ and AE<\/jats:styled-content> by IL<\/jats:styled-content>\u20104+ T cells.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>AA<\/jats:styled-content> patients have a higher incidence of various T\u2010cell\u2010driven inflammatory skin diseases than the normal population, a phenomenon which might relate to over\u2010activation of skin\u2010homing T cells and to specific immune triggers as the primary cause of inflammation. More importantly, we showed that by using AA<\/jats:styled-content> as a model disease, our approach of intra\u2010individual comparison of distinct inflammatory responses in the same patient is feasible and offers the unique possibility to gain insights into disease pathogenesis independent from genetic susceptibilities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13325","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:56:06Z","timestamp":1443488166000},"page":"2429-2435","source":"Crossref","is-referenced-by-count":19,"title":["Dissecting susceptibility from exogenous triggers: the model of alopecia areata and associated inflammatory skin diseases"],"prefix":"10.1111","volume":"29","author":[{"given":"N.","family":"Garzorz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Alsisi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Todorova","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Atenhan","sequence":"additional","affiliation":[{"name":"ZAUM \u2013 Center of Allergy and Environment Technical University of Munich and Helmholtz Center Munich Member of the German Center for Lung Research (DZL) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"ZAUM \u2013 Center of Allergy and Environment Technical University of Munich and Helmholtz Center Munich Member of the German Center for Lung Research (DZL) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lauffer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ring","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Schmidt\u2010Weber","sequence":"additional","affiliation":[{"name":"ZAUM \u2013 Center of Allergy and Environment Technical University of Munich and Helmholtz Center Munich Member of the German Center for Lung Research (DZL) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Eyerich","sequence":"additional","affiliation":[{"name":"ZAUM \u2013 Center of Allergy and Environment Technical University of Munich and Helmholtz Center Munich Member of the German Center for Lung Research (DZL) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Eyerich","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1103442"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.3049"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12164.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI551"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3645"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01077.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.02.006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09114"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03193.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12209"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31942"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01676.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008946"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104200"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.031"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041197"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.012"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.08.008"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.996549"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12184"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6621"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101814"},{"key":"e_1_2_5_24_1","first-page":"3573","article-title":"Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling","volume":"119","author":"Eyerich S","year":"2009","journal-title":"J Clin Investig"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000254125"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700915"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01862.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.839997"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142869"},{"key":"e_1_2_5_30_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1610-0387.2011.07713.x","article-title":"Systemic treatment with corticosteroids in psoriasis\u2013health care provision far beyond the S3\u2010guidelines","volume":"9","author":"Augustin M","year":"2011","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra074081"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.0098"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13325","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:03:55Z","timestamp":1695542635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/jdv.13325"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13325","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}