{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:50Z","timestamp":1791276950926,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hypohidrosis\/anhidrosis are congenital or acquired sweating impairments. Among them, acquired idiopathic generalized anhidrosis\/hypohidrosis (\n                      <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>\n                      ) is the most common, and characterized by favourable response to systemic corticosteroid, however, no clinical markers for disease severity or activity have been developed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Our aim was to verify the usefulness of serum carcinoembryonic antigen (\n                      <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>\n                      ) level monitoring as a clinical marker for disease activity of\n                      <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ten cases of\n                      <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>\n                      diagnosed at\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      sahikawa\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      edical\n                      <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\n                      niversity, from 1980 to 2014 were included in the study.\n                      <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>\n                      and\/or\n                      <jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>\n                      1 expression level was analysed using immunohistochemistry and enzyme\u2010linked immunosorbent assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>\n                      expression was restricted to the apical membrane of glandular cells in eccrine sweat glands in most of the three types of cases we examined [healthy control, patients with atopic dermatitis (\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ) or urticaria]. However,\n                      <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>\n                      expression was detected diffusely and much more intensively in eight of the 10\n                      <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>\n                      cases included in this study.\n                      <jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>\n                      1\u2010expression was much more restricted on the apical membrane of glandular cells of both the\n                      <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>\n                      cases and the other control subjects. While serum\n                      <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>\n                      levels increased in all five\n                      <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>\n                      cases examined (5.8\u201343.2 ng\/mL), it remained within normal limits in all control subjects: nine healthy individuals; 10 cases of\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ; 10 cases of idiopathic urticaria; four cases of normohidrotic cholinergic urticaria (\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      ann\u2013\n                      <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                      hitney's\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\n                      <\/jats:italic>\n                      \u2010test,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). The increased serum\n                      <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>\n                      levels in\n                      <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>\n                      decreased in conjunction with improved sweating during methyl prednisolone pulse therapy or repeated bathing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Serum\n                      <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>\n                      level may serve as a clinical marker for\n                      <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>\n                      activity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.13390","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T23:32:40Z","timestamp":1444260760000},"page":"1379-1383","source":"Crossref","is-referenced-by-count":22,"title":["Serum carcinoembryonic antigen (\n                    <scp>CEA<\/scp>\n                    ) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum\n                    <scp>CEA<\/scp>\n                    level and disease activity"],"prefix":"10.1111","volume":"30","author":[{"given":"M.","family":"Honma","sequence":"first","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Iinuma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa 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