{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:54:18Z","timestamp":1773089658277,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antihistamines (<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>) are often used to treat chronic skin diseases related to allergy and\/or pruritus. Data on the use of <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> in patients with chronic hand eczema (<jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content>) is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to investigate prevalence and determinants of <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> use in patients with <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were drawn from the German <jats:styled-content style=\"fixed-case\">CARPE<\/jats:styled-content> registry. The relationship of clinical, demographic and treatment\u2010related variables with <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> use in the past 12 months was analysed by means of logistic regression. Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) with corresponding 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were computed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1255 patients with <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content> were eligible for analysis (54.1% female; mean age: 47.1 years, standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) 13.6 years). Mean subjective disease severity was 5.0 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 2.5). 25% of the sample reported to have used <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> in the past 12 months. Significant positive associations with <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> use were identified for moderate (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 3.05, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.81\u20135.15) or severe (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 4.27, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.40\u20137.59) pruritus, a history of systemic treatment (e.g. alitretinoin) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.85, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.06\u20133.96), <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> phototherapy (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.78, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.28\u20132.46), flexural eczema (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.89, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.32\u20132.71), allergic rhinitis\/conjunctivitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.41, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.71\u20133.39) and female gender (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.58, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.16\u20132.14) in multivariate analyses (<jats:italic>N<\/jats:italic> = 1184). Significant inverse associations were found for an eczema localization besides the hands (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 0.66, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.46\u20130.94) and for patients being recruited in hospital (vs. dermatological practice; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 0.47, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.33\u20130.67).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> use is frequent in patients with <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content> and mainly related to female gender, disease severity, pruritus, comorbid atopic disease and treatment centre.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13398","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T09:04:02Z","timestamp":1444899842000},"page":"50-56","source":"Crossref","is-referenced-by-count":10,"title":["Which factors are associated with the use of systemic antihistamines in patients with chronic hand eczema? Results from the <scp>CARPE<\/scp> registry"],"prefix":"10.1111","volume":"30","author":[{"given":"C.","family":"Apfelbacher","sequence":"first","affiliation":[{"name":"Medical Sociology Institute of Epidemiology and Preventive Medicine University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wei\u00df","sequence":"additional","affiliation":[{"name":"Department of Clinical Social Medicine, Occupational and Environmental Dermatology University Hospital, Ruprecht Karls University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Molin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Ludwig Maximilian University Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Carl Gustav Carus, Technical University Dresden Dresden Germany"},{"name":"University Allergy Center (UAC) University Hospital Carl Gustav Carus, Technical University Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mahler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Erlangen, Friedrich\u2010Alexander\u2010University Erlangen Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"University Allergy Center (UAC) University Hospital Carl Gustav Carus, Technical University Dresden Dresden Germany"},{"name":"Centre for Evidence\u2010based Healthcare Medizinische Fakult\u00e4t Carl Gustav Carus, Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Elsner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatological Allergy Friedrich\u2010Schiller\u2010University Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.L.","family":"Diepgen","sequence":"additional","affiliation":[{"name":"Department of Clinical Social Medicine, Occupational and Environmental Dermatology University Hospital, Ruprecht Karls University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Department of Clinical Social Medicine, Occupational and Environmental Dermatology University Hospital, Ruprecht Karls University Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-010-2081-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07694_suppl.x"},{"key":"e_1_2_7_4_1","unstructured":"Registries for Evaluating Patient Outcomes: A User's Guide. 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