{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:20:06Z","timestamp":1790443206663,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Merkel cell carcinoma (MCC<\/jats:styled-content>) is an uncommon aggressive primary cutaneous carcinoma with neuroendocrine differentiation. However, literature data about the use of somatostatin receptor positron emission tomography\/computed tomography (PET<\/jats:styled-content>\/CT<\/jats:styled-content>) imaging in MCC<\/jats:styled-content> are limited and its role is not clearly stated.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the role of PET<\/jats:styled-content>\/CT<\/jats:styled-content> using somatostatin analogues radiolabelled with gallium\u201068 in patients with MCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>All patients affected by MCC<\/jats:styled-content> who performed a somatostatin receptor PET<\/jats:styled-content>\/CT<\/jats:styled-content> imaging from October 2007 to May 2014 were retrospectively analysed. The diagnostic performances of PET<\/jats:styled-content>\/CT<\/jats:styled-content> were evaluated on a patient\u2010based analysis and compared to final diagnosis (histology = 3 or clinical\/radiological follow\u2010up = 20).<\/jats:p><\/jats:sec>Results<\/jats:title>We evaluated 23 consecutive MCC<\/jats:styled-content> patients [18 men; median age 71 years (range 47\u201387)]. Primary tumour was located in ear (1\/23), cheek (3\/23), arm (2\/23), hand (1\/23), back (1\/23), anal canal (1\/23), gluteus (4\/23), thigh (3\/23) and popliteal fossa (1\/23). In 6\/23 patients, the site of primary tumour was unknown. PET<\/jats:styled-content>\/CT<\/jats:styled-content> was performed to detect primary tumour site (4\/23) or to stage (8\/23) or re\u2010stage (11\/23) patients. PET<\/jats:styled-content>\/CT<\/jats:styled-content> resulted positive in 14\/23 patients and according to the final diagnosis was defined true positive, true negative, false positive (FP<\/jats:styled-content>) and false negative in 11\/23, 8\/23, 3\/23 and 1\/23 cases respectively. FP PET<\/jats:styled-content>\/CT<\/jats:styled-content> results were due to unspecific liver uptake, post\u2010surgical inflammation and pancreatic neuroendocrine tumour. PET<\/jats:styled-content>\/CT<\/jats:styled-content> was unable to detect primary tumour site in all patients with unknown primary MCC<\/jats:styled-content>. Sensitivity, specificity and diagnostic accuracy of PET<\/jats:styled-content>\/CT<\/jats:styled-content> were 92%, 73% and 83% respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In our experience, somatostatin receptor PET<\/jats:styled-content>\/CT<\/jats:styled-content> imaging resulted useful in patients with MCC<\/jats:styled-content> and presented high diagnostic performances with a significant impact in disease management although in patients with unknown primary MCC<\/jats:styled-content>, it was unable to identify the primary tumour site.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13405","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T03:54:42Z","timestamp":1444276482000},"page":"1507-1511","source":"Crossref","is-referenced-by-count":10,"title":["Somatostatin receptor positron emission tomography\/computed tomography imaging in Merkel cell carcinoma"],"prefix":"10.1111","volume":"30","author":[{"given":"M.","family":"Sollini","sequence":"first","affiliation":[{"name":"Nuclear Medicine Unit Arcispedale Santa Maria Nuova \u2013 IRCCS Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Taralli","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Milella","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Regina Elena National Cancer Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Erba","sequence":"additional","affiliation":[{"name":"Regional Center of Nuclear Medicine University of Pisa Pisa 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