{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:05:10Z","timestamp":1788145510909,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Almirall Aps"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photoepilation is the treatment of choice for hair removal in patients with hirsutism, but it remains a challenge to prevent regrowth of hairs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to investigate whether topical eflornithine maintains hair reduction in hirsute patients after cessation of intense pulsed light (<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, split\u2010face, single\u2010blinded controlled trial on topical eflornithine vs. no eflornithine treatment (control) after 5\u20136 <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>\u2010treatments in 22 women with facial hirsutism. Application of eflornithine was initiated after the final <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>\u2010treatment (baseline) and applied twice daily for 6 months to half of the face. Patients were assessed at baseline and 1, 3 and 6 months after the final <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>\u2010treatment. The primary endpoint was difference in facial hair counts between eflornithine vs. no treatment. Secondary endpoints were patient\u2010evaluated efficacy, patient satisfaction and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 18 patients completed the study protocol. At 1 month after final <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>\u2010treatment, eflornithine reduced hair regrowth by 14% (<jats:italic>P<\/jats:italic> = 0.007, <jats:italic>n<\/jats:italic> = 20 patients), at 3 months by 9% (<jats:italic>P<\/jats:italic> = 0.107, <jats:italic>n<\/jats:italic> = 19) and at 6 months by 17% (<jats:italic>P<\/jats:italic> = 0.048, <jats:italic>n<\/jats:italic> = 18) compared to no treatment. Patient\u2010evaluated efficacy supported blinded hair counts and patients were satisfied with eflornithine treatment throughout the study (median <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> 5\u20136). Eflornithine was generally well tolerated, but blinded evaluation demonstrated deterioration of acne in two patients at final assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical eflornithine provides a self\u2010administered treatment with a potential to maintain <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>\u2010induced hair reduction in hirsute patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13447","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T02:48:40Z","timestamp":1446000520000},"page":"314-319","source":"Crossref","is-referenced-by-count":27,"title":["Adjuvant eflornithine to maintain <scp>IPL<\/scp>\u2010induced hair reduction in women with facial hirsutism: a randomized controlled trial"],"prefix":"10.1111","volume":"30","author":[{"given":"A.C.","family":"Vissing","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg University Hospital 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