{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:12:56Z","timestamp":1784128376031,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Israeli-German Dermatology Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photosensitive atopic dermatitis (Ph<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is a scarcely reported entity characterized clinically by a photodistributed rash in patients who fulfil the criteria for atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this retrospective study is to define significant clinical, laboratory and immunological parameters as well as photobiological features for diagnosing Ph<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010centre retrospective analysis of 17 patients with long\u2010standing <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> who in the disease course suddenly developed photosensitivity. All patients with suspected Ph<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> treated in our department between 2009 and 2014 were included in the study. Diagnostic methods were immunological parameters, prick and patch testing, histology and phototesting procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Onset of photosensitivity was observed during spring, summer and during exposure to artificial <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> (Ultraviolet radiation) as part of the patients' treatment regimen. Symptoms appeared 31.5 months on average after <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> diagnosis was established. Although the <jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content> (Minimal erythematous dose) was normal compared to a control group, all patients tested with photoprovocation methods exhibited a positive reaction. Two types of reactions were observed: papular and eczematous reactions, both types having similar histology. The wavelength spectrum most commonly involved was <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>. The disease seems to affect women more often than men. Predilection sites included face, neck, exposed trunk areas and arms. Patients with PhAD had coexistent eczematous lesions in non\u2010sun\u2010exposed skin. IgE levels were elevated in 11\/17 patients (65%), with a median value of 269 kU\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ph<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> is an underreported subset of atopic dermatitis, which is rarely diagnosed. This study suggests that several features including atopic diathesis, eczematous lesions in <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> exposed body regions and positive photoprovocation reaction are suggestive of Ph<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> as the likely diagnosis. Typically, the atopic eczema starts without a sign of photosensitivity, however, in a subgroup of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients after a few months to years, a switch occurs leading to Ph<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13451","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:02:35Z","timestamp":1446508955000},"page":"270-275","source":"Crossref","is-referenced-by-count":29,"title":["Photosensitive atopic dermatitis \u2013 a neglected subset: Clinical, laboratory, histological and photobiological workup"],"prefix":"10.1111","volume":"30","author":[{"given":"E.","family":"Ellenbogen","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv 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