{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:35:15Z","timestamp":1790141715676,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T00:00:00Z","timestamp":1447027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002468","name":"Dong-A University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002468","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical excision is conventionally regarded as the treatment of choice for nodular basal cell carcinoma (<jats:styled-content style=\"fixed-case\">nBCC<\/jats:styled-content>), and methyl aminolevulinate photodynamic therapy (<jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) has relatively low efficacy for <jats:styled-content style=\"fixed-case\">nBCC<\/jats:styled-content>. However, Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> ablative fractional laser (<jats:styled-content style=\"fixed-case\">AFL<\/jats:styled-content>)\u2010primed <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (Er:<jats:styled-content style=\"fixed-case\">YAG AFL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) may offer enhanced efficacy for <jats:styled-content style=\"fixed-case\">nBCC<\/jats:styled-content>, especially thin <jats:styled-content style=\"fixed-case\">nBCC<\/jats:styled-content> (thickness \u22642 mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We compared Er:<jats:styled-content style=\"fixed-case\">YAG AFL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> with conventional <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> for thin facial <jats:styled-content style=\"fixed-case\">nBCC<\/jats:styled-content> in Korean patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine patients (42 lesions) with primary, histologically proven thin <jats:styled-content style=\"fixed-case\">nBCC<\/jats:styled-content>s were randomized to Er:<jats:styled-content style=\"fixed-case\">YAG AFL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (single session, <jats:italic>n<\/jats:italic> = 20) or conventional <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (two sessions, 7 days apart, <jats:italic>n<\/jats:italic> = 19). Efficacy, recurrence rate, cosmetic outcomes and safety were assessed 1 week, 3 months and 12 months after the last treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three months after the final treatment, overall complete response rates were 84.2% with Er:<jats:styled-content style=\"fixed-case\">YAG AFL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> and 50% with <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.026). The recurrence rate was significantly lower with Er:<jats:styled-content style=\"fixed-case\">YAG AFL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (6.3%) than with <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (55.6%) at 12 months (<jats:italic>P<\/jats:italic> = 0.006). Er:<jats:styled-content style=\"fixed-case\">YAG AFL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> did not differ significantly with respect to cosmetic outcomes or safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Er:<jats:styled-content style=\"fixed-case\">YAG AFL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> can be used as an alternative treatment option for patients who have thin <jats:styled-content style=\"fixed-case\">nBCC<\/jats:styled-content> and are not suitable for surgical treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13453","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T00:03:12Z","timestamp":1447113792000},"page":"783-788","source":"Crossref","is-referenced-by-count":54,"title":["Er:<scp>YAG<\/scp> ablative fractional laser\u2010primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12\u2010month follow\u2010up results of a randomized, prospective, comparative trial"],"prefix":"10.1111","volume":"30","author":[{"given":"S.H.","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine Dong\u2010A University Seo\u2010gu Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Dong\u2010A University Seo\u2010gu Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.H.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Dong\u2010A University Seo\u2010gu Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.10.1177"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00535.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02673.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08666.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12319"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.06.006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.04407.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.02.014"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12242"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.2.248"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05600.x"},{"issue":"2","key":"e_1_2_5_13_1","first-page":"413","article-title":"Comparison of topical methyl aminolevulinate photodynamic therapy versus placebo photodynamic therapy in nodular BCC","volume":"18","author":"Tope WD","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510032887"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12627"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13542"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12334"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700048"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-415"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20591"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750010977"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13453","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:56:41Z","timestamp":1695513401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,9]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/jdv.13453"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13453","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,9]]}}}