{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:22:35Z","timestamp":1788524555149,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8130137381301374"],"award-info":[{"award-number":["8130137381301374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371862"],"award-info":[{"award-number":["81371862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurosyphilis is one of the most feared complications of syphilis. The question of how to identify patients at higher risk in order for timely intervention whilst avoiding unnecessary lumbar puncture remains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between August 2009 and March 2013, a total of 834 HIV\u2010negative patients with primary, secondary or latent syphilis were recruited. Venous blood and cerebrospinal fluid specimens were collected for diagnoses of syphilis and\/or neurosyphilis and information of socio\u2010demographic and behavioral characteristics was collected by interviewing with a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of neurosyphilis differed among patients with primary (7.1%), secondary (23.8%) and latent (26.6%) syphilis. Neurosyphilis was more likely in male patients (1.52\u2010fold). Compared with patients aged &lt;30 years, those aged 45\u201359 years and \u226560 years old had a 2.51\u2010fold and 4.98\u2010fold risk of neurosyphilis respectively. Male gender and age \u226545 years were consistently associated with neurosyphilis both in secondary and latent stage. There was a 2.68\u2010fold, 2.55\u2010fold and 3.67\u2010fold increased risk of neurosyphilis when the serum RPR titer was 1:32, 1:64 and \u22651:128 compared to that of \u22641:16. ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Male gender and age 45years are both correlated risk factors for neurosyphilis in HIV\u2010negative patients with primary, secondary and latent syphilis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13514","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T03:20:05Z","timestamp":1449804005000},"page":"659-666","source":"Crossref","is-referenced-by-count":46,"title":["Risk profiles of neurosyphilis in <scp>HIV<\/scp>\u2010negative patients with primary, secondary and latent syphilis: implications for clinical intervention"],"prefix":"10.1111","volume":"30","author":[{"given":"M.","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Sexually Transmitted Disease Institute 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