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How they interact with the innate and adaptive immune systems is unknown. Their potential to have a pathogenic role in the causation of human skin disorders causes continued speculation. With growing interest in the microflora of human skin and its relevance to cutaneous health, the role of <jats:italic>Demodex<\/jats:italic> mites needs to be better understood. The main challenges facing scientists investigating the role of these organisms and possible solutions are reviewed under the following headings: (1) Determining the mite population in skin, (2) Transporting, extracting and imaging live mites, (3) Maintaining mites viable <jats:italic>ex vivo<\/jats:italic> and (4) Establishing methods to determine the immune response to <jats:italic>Demodex<\/jats:italic> mites and their internal contents.<\/jats:p>","DOI":"10.1111\/jdv.13517","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T12:36:40Z","timestamp":1450874200000},"page":"764-775","source":"Crossref","is-referenced-by-count":48,"title":["Study of <i>Demodex<\/i> mites: Challenges and Solutions"],"prefix":"10.1111","volume":"30","author":[{"given":"N.","family":"Lacey","sequence":"first","affiliation":[{"name":"The Charles Institute of Dermatology University College Dublin Belfield Dublin 4 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Russell\u2010Hallinan","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology University College Dublin Belfield Dublin 4 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.C.","family":"Powell","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology University College Dublin Belfield Dublin 4 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Demodex folliculorum. 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