{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:13:10Z","timestamp":1785795190384,"version":"3.56.0"},"reference-count":9,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with rosacea often show facial sensitivity to cosmetics or skin care products that can influence the severity of symptoms and exacerbate erythema and inflammation. Nevertheless, special skin care is necessary to address cosmetic concerns and reduce the potential side\u2010effects of topical or oral treatment of the disease. Appropriate skin care should comprise gentle cleansing, effective moisturization, soothing actives, <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> protection and concealing pigments to help neutralize the appearance of redness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the compatibility and efficacy of a skin care regimen (consisting of a cleanser, a day care with <jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content>25 and a night care) containing licochalcone A (Lic A), an anti\u2010irritant from the licorice plant <jats:italic>Glycyrrhiza inflata<\/jats:italic>, and 4\u2010t\u2010butylcyclohexanol (SymSitive<jats:sup>\u00ae<\/jats:sup>), a substance which acts as a sensitivity regulator, in female subjects with clinically determined subtype I rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two test subjects with mild to moderate rosacea used the skin care regimen daily for 8\u00a0weeks. Clinical assessment of erythema, subjective irritation and clinical photography were performed at baseline and after 4 and 8\u00a0weeks. Additionally, a quality\u2010of\u2010life questionnaire was filled out by the test subjects at baseline and week 8. The subjects completed a self\u2010assessment questionnaire on product properties after 4 and 8\u00a0weeks of product use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical assessments and subject response confirmed very good tolerability of the regimen, a statistically significant improvement in clinical grading for erythema and tactile roughness at weeks 4 and 8 and on telangiectasia at week 8 when compared to baseline scores. A statistically significant improvement in facial redness (a*) values, based on the L*a*b* colorimetric system, was determined at week 4 and 8 in comparison to baseline. No difference in corneometric measurement was detected at week 4 and 8 compared to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The skin care regimen was found to be highly compatible with the sensitive facial skin of patients with rosacea subtype I and effective in improving signs of rosacea. Therefore, the daily use of skin care products containing LicA and SymSitive<jats:sup>\u00ae<\/jats:sup> in patients with rosacea improves the overall skin appearance and the quality of life of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13531","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T12:20:34Z","timestamp":1453724434000},"page":"21-27","source":"Crossref","is-referenced-by-count":31,"title":["Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4\u2010t\u2010butylcyclohexanol in patients with rosacea subtype I"],"prefix":"10.1111","volume":"30","author":[{"given":"A.M.","family":"Schoelermann","sequence":"first","affiliation":[{"name":"Beiersdorf AG Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"Weber","sequence":"additional","affiliation":[{"name":"Beiersdorf Inc. Wilton CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Arrowitz","sequence":"additional","affiliation":[{"name":"Beiersdorf Inc. Wilton CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Rizer","sequence":"additional","affiliation":[{"name":"TJ Stephens &amp; Associates Colorado Springs CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Qian","sequence":"additional","affiliation":[{"name":"TJ Stephens &amp; Associates Colorado Springs CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Babcock","sequence":"additional","affiliation":[{"name":"TJ Stephens &amp; Associates Colorado Springs CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"National Rosacea Society.Skin Care & Cosmetics. [WWW document] URLhttp:\/\/www.rosacea.org\/patients\/skincare\/index.php(last assessed: July 6 2015)"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01697.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00861.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01122.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12588"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0654-4"},{"key":"e_1_2_5_8_1","volume-title":"Licochalcone A Protects From Reactive Oxygen Speciens Induced by High Energy Visible Light at Common Ambient Solar Doses. Poster, 23rd World Congress of Dermatology","author":"Mann A","year":"2015"},{"key":"e_1_2_5_9_1","first-page":"241","article-title":"Assessment of the influence of licochalcone on selected functional skin parameters in patients with impaired vasomotor disorders and rosacea","author":"Broniarczyk\u2010Dyla G","year":"2011","journal-title":"Postepy Dermatologii i Alergologii"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2006.00261.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13531","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T19:26:59Z","timestamp":1694546819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,25]]},"references-count":9,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/jdv.13531"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13531","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,25]]}}}