{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:18:12Z","timestamp":1791353892574,"version":"4.3.1"},"reference-count":87,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sensitive skin is a clinical condition defined by the self\u2010reported facial presence of different sensory perceptions, including tightness, stinging, burning, tingling, pain and pruritus. Sensitive skin may occur in individuals with normal skin, with skin barrier disturbance, or as a part of the symptoms associated with facial dermatoses such as rosacea, atopic dermatitis and psoriasis. Although experimental studies are still pending, the symptoms of sensitive skin suggest the involvement of cutaneous nerve fibres and neuronal, as well as epidermal, thermochannels. Many individuals with sensitive skin report worsening symptoms due to environmental factors. It is thought that this might be attributed to the thermochannel <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1, as it typically responds to exogenous, endogenous, physical and chemical stimuli. Barrier disruptions and immune mechanisms may also be involved. This review summarizes current knowledge on the epidemiology, potential mechanisms, clinics and therapy of sensitive skin.<\/jats:p>","DOI":"10.1111\/jdv.13532","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T12:20:34Z","timestamp":1453724434000},"page":"2-8","source":"Crossref","is-referenced-by-count":162,"title":["Sensitive skin"],"prefix":"10.1111","volume":"30","author":[{"given":"L.","family":"Misery","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Loser","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"St\u00e4nder","sequence":"additional","affiliation":[{"name":"Center for Chronic Pruritus (KCP) University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00861.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.2013.856688"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01697.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(98)90020-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08280.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01288.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.03037.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.04884.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02027.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04343.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(05)79303-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12027"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2014.2367"},{"key":"e_1_2_6_15_1","volume-title":"Sample Survey Methods and Theory","author":"Hansen MH","year":"1993"},{"key":"e_1_2_6_16_1","first-page":"112","article-title":"Sensitive skin in the United Sates: Surveys of regional differences","volume":"2","author":"Farage MA","year":"2013","journal-title":"Family Med Medical Sci Res"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(97)90000-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb02069.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02134.x"},{"key":"e_1_2_6_20_1","first-page":"17","article-title":"Objective biophysical findings in patients with sensitive skin","volume":"31","author":"Roussaki\u2010Schulze AV","year":"2005","journal-title":"Drugs Exp Clin Res"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb01477.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084911"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2010.00478.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155501317140052"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08585.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12253"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.01.016"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0452-6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328364ebeb"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.138"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050179"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050167"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13974"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-011-2208-8"},{"key":"e_1_2_6_35_1","first-page":"119","article-title":"The epidermis: a sensory tissue","volume":"18","author":"Boulais N","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00158.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00529.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.040204.100431"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.055624"},{"key":"e_1_2_6_40_1","first-page":"2568","article-title":"TRP channels in the skin","volume":"171","author":"T\u00f3th BI","year":"2014","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-012-1081-3"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-0265-3_44"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01851.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3456"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2006"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12163"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.112958"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23209.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.04.031"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.421"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700590"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.87"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00806.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.02.020"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/857123"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081228"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01122.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.0178.x"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.11.003"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.424"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13306"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3009"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13199"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00754.x"},{"key":"e_1_2_6_66_1","first-page":"13","article-title":"[Le SIGL: un outil d\u2019\u00e9valuation clinique des peaux r\u00e9actives]","volume":"26","author":"Gougerot A","year":"2007","journal-title":"Nouv Dermatol"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1870"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03968.x"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12236"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32835804c5"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.914"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0266"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1315"},{"key":"e_1_2_6_75_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1600-0625.2011.01389.x","article-title":"The itchy scalp\u2013scratching for an explanation","volume":"20","author":"Bin S","year":"2011","journal-title":"Exp Dermatol"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11070.x"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246391"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-011-2210-1"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363149"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13466"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321066"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.08.014"},{"key":"e_1_2_6_83_1","first-page":"245","volume-title":"Dermatology: Clinical and Basic Science Series. Sensitive Skin Syndrome","author":"Draelos ZD","year":"2006"},{"key":"e_1_2_6_84_1","first-page":"405","article-title":"Evaluation of a topical treatment for the relief of sensitive skin","volume":"8","author":"Heinicke IR","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12720"},{"key":"e_1_2_6_86_1","first-page":"375","article-title":"Effectiveness of pimecrolimus cream for women patients with sensitive skin and its underlying mechanism","volume":"34","author":"Xie Z","year":"2012","journal-title":"Zhongguo yi xue ke xue Yuan xue bao"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-013-1281-x"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2013.0001"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13532","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T19:27:08Z","timestamp":1694546828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,25]]},"references-count":87,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/jdv.13532"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13532","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,25]]}}}