{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:20:03Z","timestamp":1781623203852,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Topical photodynamic therapy (PDT<\/jats:styled-content>) is an effective treatment for superficial non\u2010melanoma skin cancers. Two prodrugs, 5\u2010aminolevulinic acid (ALA<\/jats:styled-content>) and methyl aminolevulinate (MAL<\/jats:styled-content>), are available for clinical use. There is, however, a lack of studies comparing the clinical effectiveness of these two prodrugs.<\/jats:p><\/jats:sec>Objective<\/jats:title>The objective of the study was to compare the clinical response between ALA<\/jats:styled-content>\u2010 and MAL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> when treating actinic keratosis (AK<\/jats:styled-content>), Bowen's disease (BD<\/jats:styled-content>), nodular basal cell carcinoma (nBCC<\/jats:styled-content>) and superficial basal cell carcinoma (sBCC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>During the period 2002\u20132009, patients with AK<\/jats:styled-content>, BD<\/jats:styled-content>, nBCC<\/jats:styled-content> and sBCC<\/jats:styled-content> were treated with ALA<\/jats:styled-content>\u2010 and MAL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> at the Department of Dermatology at Karlskoga Hospital in Sweden using a fixed protocol. All patients were followed up approximately 6 months after treatment to evaluate the clinical results, which were analysed retrospectively.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 116 patients with 203 tumours were treated with PDT<\/jats:styled-content> during the study period. ALA<\/jats:styled-content>\u2010 and MAL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> were used for 24 vs. 44 AK<\/jats:styled-content> fields, 9 vs. 18 BD<\/jats:styled-content> lesions, 19 vs. 25 nBCC<\/jats:styled-content>s and 25 vs. 39 sBCC<\/jats:styled-content>s. Response rates with ALA<\/jats:styled-content>\u2010 and MAL<\/jats:styled-content>\u2010PDT<\/jats:styled-content>, respectively, were 63% and 75% for AK<\/jats:styled-content>, 89% and 78% for BD<\/jats:styled-content>, 84% and 84% for nBCC<\/jats:styled-content> and 88% and 87% for sBCC<\/jats:styled-content>. There were no statistically significant differences in the complete clinical response rates for ALA<\/jats:styled-content>\u2010 and MAL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> when used for any of the four lesion types.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>ALA\u2010 and MAL<\/jats:styled-content>\u2010PDT<\/jats:styled-content> appear to be equally effective in the treatment of AK<\/jats:styled-content>, BD<\/jats:styled-content>, nBCC<\/jats:styled-content> and sBCC<\/jats:styled-content>. Nevertheless, larger, prospective, randomized and controlled studies should be carried out to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13558","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T18:28:49Z","timestamp":1454524129000},"page":"420-423","source":"Crossref","is-referenced-by-count":55,"title":["Aminolevulinic acid and methyl aminolevulinate equally effective in topical photodynamic therapy for non\u2010melanoma skin cancers"],"prefix":"10.1111","volume":"30","author":[{"given":"M.","family":"Tarstedt","sequence":"first","affiliation":[{"name":"Department of Dermatology Karlskoga Hospital Karlskoga Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gillstedt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital Institute of Clinical Sciences at the Sahlgrenska Academy University of Gothenburg Gothenburg 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