{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:20:28Z","timestamp":1781169628103,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) is an autoimmune\u2010related chronic inflammatory disease, which appears mostly in skin, but also affects the vascular and metabolic system. The incidence of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> is 2\u20133% in the general population and there is still no possibility to cure. Trigger factors have been identified to initiate and maintain inflammation in the skin, which is characterized by Th1\u2010, Th17\u2010 and Th22\u2010 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We hypothesize that the damage\u2010associated molecular pattern (<jats:styled-content style=\"fixed-case\">DAMP<\/jats:styled-content>) molecule high mobility group box 1 (<jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1) plays a role in the pathogenesis of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 is a <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010binding protein located in the nucleus, which acquires cytokine\u2010like properties once released from the cell upon necrotic cell death or actively secreted by immune cells in inflammation and cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 90 psoriatic patients under and without therapy with mild, intermediate and severe progression of disease, defined by the Psoriasis Area Severity Index. Serum levels of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 in patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> were detected by enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results show an increased level of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 in the sera of patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> in comparison to healthy donors. Furthermore, our analyses reveal that <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 levels are significantly increased with disease progression and are downregulated after standard therapies for <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> have been conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data provide insights into a possible role of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 for inflammation in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13564","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T11:38:51Z","timestamp":1454413131000},"page":"435-441","source":"Crossref","is-referenced-by-count":30,"title":["High mobility group box 1 is increased in the sera of psoriatic patients with disease progression"],"prefix":"10.1111","volume":"30","author":[{"given":"C.","family":"Bergmann","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Strohbuecker","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sucker","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Joosten","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Koenen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"K\u00f6rber","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.023"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04599.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04410.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1330-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.139"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12152"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/295081"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(80)80453-4"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.9.3747-3756.2004"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110233200"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg516"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.248"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3906"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1372"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-200501000-00001"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.02.006"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4049\/jimmunol.134.1.157","article-title":"In vivo administration of purified human interleukin 2. 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