{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:08:16Z","timestamp":1791324496728,"version":"4.3.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Acanthosis nigricans (AN<\/jats:styled-content>) can occur as a cutaneous manifestation of genetic diseases, one of which is associated with activating mutations of the fibroblast growth factor receptor 3 gene (FGFR<\/jats:styled-content>3<\/jats:italic>).<\/jats:p><\/jats:sec>Objective<\/jats:title>We explored familial AN<\/jats:styled-content> patients with FGFR<\/jats:styled-content>3<\/jats:italic> mutations and examined the effectiveness of glycolic acid (GA<\/jats:styled-content>) peeling in improving their skin manifestations.<\/jats:p><\/jats:sec>Methods<\/jats:title>Sanger sequencing was performed for the genomic DNA<\/jats:styled-content> extracted from leucocytes of the family members involving familial AN<\/jats:styled-content>. GA<\/jats:styled-content> peeling was carried out for the two patients of familial AN<\/jats:styled-content> once every 2 weeks.<\/jats:p><\/jats:sec>Results<\/jats:title>Heterozygous c.1949A>C (p.K650T) mutation in FGFR<\/jats:styled-content>3<\/jats:italic> was identified for the affected family members examined, whereas the wild\u2010type sequence was found for two unaffected individuals. Hyperpigmentation and coarseness of the skin were improved by GA<\/jats:styled-content> peeling at regular intervals with few adverse effects.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We diagnosed our cases as familial generalized AN<\/jats:styled-content> caused by heterozygous c.1949A>C (p.K650T) mutation of FGFR<\/jats:styled-content>3<\/jats:italic>. We propose that GA<\/jats:styled-content> peeling is a useful and safe therapeutic option to treat familial AN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13580","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T03:08:40Z","timestamp":1453950520000},"page":"442-445","source":"Crossref","is-referenced-by-count":21,"title":["Effective treatment by glycolic acid peeling for cutaneous manifestation of familial generalized acanthosis nigricans caused by FGFR<\/scp>3<\/i> mutation"],"prefix":"10.1111","volume":"30","author":[{"given":"S.","family":"Ichiyama","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Funasaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Hospital Tokyo 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