{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:12:13Z","timestamp":1783080733641,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The number of medical devices designed specifically to treat onychomycosis has recently increased, although their mechanism of action is not clear. We evaluated available laser therapies for onychomycosis by reviewing the existing literature. Twenty\u2010two reports, published in peer\u2010reviewed journals and as white papers out of 926 initial search results conveyed enough details to be included in this study. In most cases, the methodology of the trials described in the papers we reviewed was not comprehensive and the reporting of outcomes was not unified. We therefore found it hard to compare different clinical trials to one another. The majority of studies (81.82%) reported using an Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>laser device to treat onychomycosis. A total of 47.37% of the studies which used a 1064 device (and 47.83% of all studies we reviewed) reported that all treated patients responded positively to laser therapy. A total of 60% of studies reported achieving a complete cure (no clinical symptoms, nor negative mycology) in at least 50% of the treated patients. A low number of adverse events and their mild intensity were consistently reported across all studies, which makes this form of therapy particularly attractive to patients with contraindications for receiving systemic antifungal medication. In order to achieve more unified, comparable studies in the future, we suggest that researchers report a minimum set of outcome measurements: the calculation of the infected nail area pre\u2010 and posttreatment, as well as the number of patients achieving mycological, clinical and complete cures.<\/jats:p>","DOI":"10.1111\/jdv.13593","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T06:48:06Z","timestamp":1457419686000},"page":"936-942","source":"Crossref","is-referenced-by-count":38,"title":["Laser therapies for onychomycosis \u2013 critical evaluation of methods and effectiveness"],"prefix":"10.1111","volume":"30","author":[{"given":"W.","family":"Francuzik","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fritz","sequence":"additional","affiliation":[{"name":"Hautaerzte und Laserzentrum Landau Landau in der Pfalz Germany"},{"name":"Department of Dermatology and Health Sciences University Osnabr\u00fcck Osnabr\u00fcck Germany"},{"name":"2nd Department of Dermatology Colentina Hospital \u2013 EADV Center of Excellence on Corrective Dermatology Carol Davila University of Medicine and Pharmacy Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Salavastru","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology Colentina Hospital \u2013 EADV Center of Excellence on Corrective Dermatology Carol Davila University of Medicine and Pharmacy Bucharest 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