{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:04:46Z","timestamp":1775779486880,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"GlaxoSmithKline (China)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Acne vulgaris affects up to 54% of Chinese adolescents. Combination therapy has become the recommended standard of care for acne.<\/jats:p><\/jats:sec>Objective<\/jats:title>The aim of this study was to compare the efficacy and safety of clindamycin (1%) and benzoyl peroxide (5%) (CDP<\/jats:styled-content>\/BPO<\/jats:styled-content>) gel once daily vs. clindamycin (1%) (CDP<\/jats:styled-content>) monotherapy gel twice daily in Chinese patients with mild to moderate acne.<\/jats:p><\/jats:sec>Methods<\/jats:title>1020 patients (aged 12\u201345 years) with mild to moderate acne were randomized (1 : 1); 1016 patients were treated with CDP<\/jats:styled-content>\/BPO<\/jats:styled-content> (n<\/jats:italic> = 500) or CDP<\/jats:styled-content> (n<\/jats:italic> = 516) for a 12\u2010week treatment period. Efficacy assessments were performed at baseline, and at weeks 1, 2, 4, 8 and 12; and primarily included change in total lesion count (inflammatory and non\u2010inflammatory lesions), and proportion of patients with a minimum 2\u2010grade improvement in Investigator's Static Global Assessment (ISGA<\/jats:styled-content>) score. Patient safety and local tolerability were also evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients in CDP<\/jats:styled-content>\/BPO<\/jats:styled-content> group showed a greater per cent reduction in total lesion count compared with patients in CDP<\/jats:styled-content> group at week 12 (delta = \u22120.05; 95% CI<\/jats:styled-content> = \u22120.09, \u22120.02; P<\/jats:italic> = 0.003); statistically significant reduction in lesion count was noted as early as week 1 and continued through week 12. A greater proportion of patients in CDP<\/jats:styled-content>\/BPO<\/jats:styled-content> group showed a \u22652\u2010grade improvement in ISGA<\/jats:styled-content> score at week 12 compared with CDP<\/jats:styled-content> group (30.2% vs. 22.7%; P<\/jats:italic> = 0.018). Overall, the incidence of adverse events (AE<\/jats:styled-content>s) was higher in the CDP<\/jats:styled-content>\/BPO<\/jats:styled-content> group (14.4%) than in the CDP<\/jats:styled-content> group (7.9%); the most commonly reported events were generally related to application site reactions (erythema, pruritus and swelling). Incidence of drug\u2010related AE<\/jats:styled-content>s was 8.6% in CDP<\/jats:styled-content>\/BPO<\/jats:styled-content> group and 1.2% in CDP<\/jats:styled-content> group. Both groups showed trends towards reduction in investigator and subject rated local tolerability scores.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CDP<\/jats:styled-content>\/BPO<\/jats:styled-content> gel demonstrated superior efficacy over CDP<\/jats:styled-content> gel along with acceptable safety and tolerability in Chinese patients with mild to moderate acne.<\/jats:p><\/jats:sec>Clinical Trials.gov number: NCT01915732<\/jats:title><\/jats:sec>","DOI":"10.1111\/jdv.13622","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T08:57:20Z","timestamp":1460537840000},"page":"1176-1182","source":"Crossref","is-referenced-by-count":7,"title":["A multicentre, randomized, single\u2010blind comparison of topical clindamycin 1%\/benzoyl peroxide 5% once\u2010daily gel versus clindamycin 1% twice\u2010daily gel in the treatment of mild to moderate acne vulgaris in Chinese patients"],"prefix":"10.1111","volume":"30","author":[{"given":"J.H.","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.J.","family":"Lu","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Medical Epigenomics Department of Dermatology Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Third Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing 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