{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:49Z","timestamp":1791276949788,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Psoriasis is a multi\u2010systemic disease involving the skin and joints, but it is also characterized by endothelial dysfunction, which may cause sexual impotence and erectile dysfunction (\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      ), an embarrassing disease frequently neglected by dermatologists.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The principal objective was assessing the relationship between the severity of psoriasis and the severity of\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      . We also investigated whether severity of psoriasis was related to International Index of Erectile Function\u20105 (\n                      <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                      \u20105) score, whether genital lesions worsened the\n                      <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                      \u20105 score, whether\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      was related to factors such as diabetes, smoking and hypertension, and finally the overall the psychological factors felt by the patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We administered two questionnaires (one of which was the\n                      <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                      \u20105, a validated score to assess erectile dysfunction) to three groups of patients: 60 with mild psoriasis, 60 with severe psoriasis (assessed by Psoriasis Area Severity Index, PASI) and a control group including 60 patients without the disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the group of mild psoriasis, the patients who suffered from\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      were the 56.67%, while in the group of severe psoriasis,\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      affected the 46.68% of subjects. In the control group,\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      was reported by the 23.33% of patients. The average\n                      <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                      \u20105 score was 18.81 for patients with mild psoriasis and 20.31 for patients with severe form. The difference in the average\n                      <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                      \u20105 scores between psoriatic (mild and severe cases) and control group was not statistically significant. Most patients with sexual dysfunction had also genital lesions; diabetes, smoking and hypertension were not related to lower\n                      <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                      \u20105 scores. The overall psychological profile of psoriatic patients was worse than that of the controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We concluded that\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      was related to psoriasis, in particular to mild forms. Moreover, since\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      is a marker of cardiovascular events, also related to negative impact on the quality of life, physicians should always investigate the presence of\n                      <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                      in clinical practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.13625","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T21:53:23Z","timestamp":1458338003000},"page":"1342-1348","source":"Crossref","is-referenced-by-count":22,"title":["Sex and the\n                    <scp>PASI<\/scp>\n                    : patients affected by a mild form of psoriasis are more predisposed to have a more severe form of erectile dysfunction"],"prefix":"10.1111","volume":"30","author":[{"given":"F.","family":"Bardazzi","sequence":"first","affiliation":[{"name":"Dermatology Unit Department of Specialistic, Diagnostic and Experimental Medicine S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Odorici","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Specialistic, Diagnostic and Experimental Medicine S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Specialistic, Diagnostic and Experimental Medicine S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Magnano","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Specialistic, Diagnostic and Experimental Medicine S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Balestri","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Specialistic, Diagnostic and Experimental Medicine S. Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Patrizi","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Specialistic, Diagnostic and Experimental Medicine S. 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