{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:49Z","timestamp":1791276949429,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      There are several clinical and histological classification systems for grading actinic keratosis (\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      ) lesions. The Olsen clinical classification scheme grades\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      lesions according to their thickness and degree of hyperkeratosis (grades 1\u20133). The Roewert\u2010Huber histological classification system grades\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      lesions based on the extent of epidermal atypical keratinocytes (\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      I\u2013\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to determine whether there is a correlation between these clinical and histological\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      classification schemes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      lesion from patients in three pivotal clinical studies and routine practice was assessed clinically and histologically. A match in grading was defined as Olsen grade 1 being classified histologically as\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      I, Olsen grade 2 as\n                      <jats:styled-content style=\"fixed-case\">AK II<\/jats:styled-content>\n                      and Olsen grade 3 as\n                      <jats:styled-content style=\"fixed-case\">AK III<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 892 lesions included, 29.0% were classified as Olsen grade 1, 59.6% as Olsen grade 2 and 11.3% as Olsen grade 3; 19.2% were histologically classified as\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      I, 69.6% as\n                      <jats:styled-content style=\"fixed-case\">AK II<\/jats:styled-content>\n                      and 11.2% as\n                      <jats:styled-content style=\"fixed-case\">AK III<\/jats:styled-content>\n                      . Only 480 lesions (53.8%) had a matching clinical and histological classification. Of these matches, most were \u2018Olsen grade 2 =\n                      <jats:styled-content style=\"fixed-case\">AK II<\/jats:styled-content>\n                      \u2019 (83.1%). The Spearman's rank correlation coefficient for clinical and histological classification was\n                      <jats:italic>r<\/jats:italic>\n                      = 0.0499 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.137).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Clinical classification of\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      lesions using the system of Olsen does not accurately match histological classification of the same lesions using the system of Roewert\u2010Huber. Consequently, it is not possible to draw conclusions about the histology of\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      lesions from their clinical appearance. This finding reinforces the need to treat all\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      lesions as well as field cancerization.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.13626","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T22:58:41Z","timestamp":1457477921000},"page":"1303-1307","source":"Crossref","is-referenced-by-count":110,"title":["Actinic keratosis: correlation between clinical and histological classification systems"],"prefix":"10.1111","volume":"30","author":[{"given":"L.","family":"Schmitz","sequence":"first","affiliation":[{"name":"Department of Dermatology Ruhr\u2010University Bochum Germany"},{"name":"CentroDerm GmbH Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kahl","sequence":"additional","affiliation":[{"name":"Heinz\u2010Werner\u2010Seifert\u2010Institute of 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