{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:49Z","timestamp":1791276949213,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T00:00:00Z","timestamp":1459555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T00:00:00Z","timestamp":1459555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016239","name":"Dutch Ministry of Economic Affairs, Agriculture and Innovation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016239","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Provinces of Gelderland and Overijssel","award":["PID102050"],"award-info":[{"award-number":["PID102050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Reflectance confocal microscopy (\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      ) is gradually implemented in dermatology. Strategies for further implementation and practical \u2018hands on\u2019 guidelines are lacking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The primary outcome was to conduct a general strategy for further implementation of\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      . The secondary outcome was the diagnosis of psoriasis and differentiation of stable from unstable psoriatic plaques by means of the \u2018hands on\u2019 protocol, derived from the strategy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used a four\u2010phased model; an exploring phase, a systematic literature search, a clinical approach and, finally, an integration phase to develop a clinical guideline for\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      in psoriasis. Receiver operating characteristic curve statistics was applied to define the accuracy for the diagnosis of unstable psoriasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A general strategy for further implementation of\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      and practical approach was developed to examine psoriasis by\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      and to distinguish stable from unstable psoriasis. Unstable psoriasis was diagnosed by epidermal inflammatory cell counts with a sensitivity and specificity of 91.7% and 98.3%, respectively, and with an accuracy of 0.92 (area under the curve). In addition, a monitoring model was proposed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This is the first study that shows a method for implementation of\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      in dermatology. The strategy and hands on protocol for psoriasis may serve as a model for other dermatological entities and additionally may lead to specialized ready\u2010to\u2010use\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      protocols for clinical dermatological practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.13627","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T17:17:30Z","timestamp":1459617450000},"page":"1308-1314","source":"Crossref","is-referenced-by-count":12,"title":["A four\u2010phase strategy for the implementation of reflectance confocal microscopy in dermatology"],"prefix":"10.1111","volume":"30","author":[{"given":"L.","family":"Hoogedoorn","sequence":"first","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.P.","family":"Gerritsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.W.","family":"Wolberink","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Peppelman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.C.M.","family":"van de Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.E.J.","family":"van Erp","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12606215"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-21997-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.172"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.12.1597"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13499"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03134.x"},{"key":"e_1_2_5_9_1","first-page":"337","article-title":"Characterization of psoriasis in\u00a0vivo by reflectance confocal microscopy","volume":"30","author":"Gonzalez S","year":"1999","journal-title":"J Med"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12345"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20575"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12062"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13235"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12150"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10988.x"},{"key":"e_1_2_5_16_1","unstructured":"International Confocal Group. 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