{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:03:09Z","timestamp":1791360189452,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Abstract<\/jats:title>\n \n Bullous pemphigoid (\n BP<\/jats:styled-content>\n ) is a chronic, autoimmune vesiculobullous disease that frequently occurs in the elderly population. Previous epidemiological studies have suggested an association between\n BP<\/jats:styled-content>\n and neurological diseases; some studies, however, showed conflicting results. This study aimed to investigate if patients with\n BP<\/jats:styled-content>\n have significantly higher risks for neurological disorders, compared to controls. A comprehensive search was performed using\n MEDLINE<\/jats:styled-content>\n ,\n EMBASE<\/jats:styled-content>\n and Cochrane library databases. Case\u2013control and cohort studies that assessed the relationship between\n BP<\/jats:styled-content>\n and neurological diseases were included. DerSimonian and Laird random\u2010effects models were utilized to calculate the pooled relative risks (\n RR<\/jats:styled-content>\n s). Publication bias was evaluated qualitatively by constructing a funnel plot and quantitatively by conducting Egger's test. Fourteen studies, with 23 369\n BP<\/jats:styled-content>\n cases and 128 697 controls were included in this meta\u2010analysis. Patients with\n BP<\/jats:styled-content>\n were significantly more likely to have stroke (\n RR<\/jats:styled-content>\n 2.68, 95%\n CI<\/jats:styled-content>\n : 2.07\u20133.46), Parkinson's disease (\n PD<\/jats:styled-content>\n ;\n RR<\/jats:styled-content>\n 3.42, 95%\n CI<\/jats:styled-content>\n : 3.01\u20133.87), dementia (\n RR<\/jats:styled-content>\n 4.46, 95%\n CI<\/jats:styled-content>\n : 3.23\u20136.16), epilepsy (\n RR<\/jats:styled-content>\n 2.98, 95%\n CI<\/jats:styled-content>\n : 1.42\u20136.28), multiple sclerosis (\n RR<\/jats:styled-content>\n 12.40, 95%\n CI<\/jats:styled-content>\n : 6.64\u201323.17) and any aforementioned neurological disease (\n RR<\/jats:styled-content>\n 4.93, 95%\n CI<\/jats:styled-content>\n : 3.62\u20136.70), compared to controls. Moderate to high heterogeneity were observed for analyses of most neurological diseases, except for\n PD<\/jats:styled-content>\n and multiple sclerosis. This study provided support for a significant association between\n BP<\/jats:styled-content>\n and neurological diseases. Clinicians should be aware of this association and manage modifiable risk factors for neurological diseases accordingly.\n <\/jats:p>","DOI":"10.1111\/jdv.13660","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T08:43:36Z","timestamp":1473237816000},"page":"2007-2015","source":"Crossref","is-referenced-by-count":109,"title":["Bullous pemphigoid and its association with neurological diseases: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Y.C.","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Dermatology Rutgers New Jersey Medical School Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.W.","family":"Yew","sequence":"additional","affiliation":[{"name":"National Skin Centre Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.C.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rutgers New Jersey Medical School Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1967.03120220053008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.19"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06338.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.35"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9866-z"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142516"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09122.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_5_11_1","unstructured":"WellsGA SheaB O'ConnellDet al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses. 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