{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:19:03Z","timestamp":1777933143895,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Focal vitiligo is characterized by depigmented patches located in a small area without a typical segmental distribution. Focal vitiligo is classified as an undetermined type of vitiligo, and a more definitive diagnosis can be made when the lesions have not evolved into non\u2010segmental or segmental vitiligo after a period of 1\u20132 years. However, the chance of progression is not known and may lead to treatment\u2010indecision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective was to study the characteristics of patients with focal vitiligo and possible predictors of progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a survey study in patients with initial diagnosis of focal vitiligo between January 2005 and June 2010. Focal vitiligo was defined as either a small acquired isolated depigmented lesion without typical segmental distribution, or two to three small acquired lesions localized in a non\u2010segmental area with a maximum of 5 cm. The survey comprised of 21 questions concerning the patient's characteristics, the onset of focal vitiligo, progression of depigmentation and treatment history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 128 eligible patients and the response rate was 40.6% (<jats:italic>n<\/jats:italic> = 52 completed questionnaires). Progression to non\u2010segmental vitiligo occurred in 23%. The median follow\u2010up duration was 7 years. In 11.5% of the patients, progression to non\u2010segmental vitiligo occurred within 2 years after onset. Nevertheless, even after a first stable period of more than 2 years, another 11.5% of the patients advanced to non\u2010segmental vitiligo. No associated prognostic factors at baseline of progression to non\u2010segmental or long\u2010lasting focal vitiligo were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Focal vitiligo is a rare subtype of vitiligo and most patients have long\u2010lasting focal lesions after onset of the disease. In this study, focal vitiligo progressed to typical non\u2010segmental vitiligo, but not towards typical segmental vitiligo. Progression 2 years after onset of focal vitiligo, occurs in 50% of the patients with eventual progression to non\u2010segmental vitiligo. There seem to be no clinical signs that predict progression in focal vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13663","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T16:51:16Z","timestamp":1460307076000},"page":"1550-1554","source":"Crossref","is-referenced-by-count":10,"title":["Focal vitiligo: long\u2010term follow\u2010up of 52 cases"],"prefix":"10.1111","volume":"30","author":[{"given":"J.E.","family":"Lommerts","sequence":"first","affiliation":[{"name":"Department of Dermatology Netherlands Institute for Pigment Disorders (NIPD) Academic Medical Centre (AMC) Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Schilder","sequence":"additional","affiliation":[{"name":"Department of Dermatology Netherlands Institute for Pigment Disorders (NIPD) Academic Medical Centre (AMC) Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"de Rie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Netherlands Institute for Pigment Disorders (NIPD) Academic Medical Centre (AMC) Amsterdam The Netherlands"},{"name":"Department of Dermatology Free University Medical Centre(VUmc) Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wolkerstorfer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Netherlands Institute for Pigment Disorders (NIPD) Academic Medical Centre (AMC) Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.W.","family":"Bekkenk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Netherlands Institute for Pigment Disorders (NIPD) Academic Medical Centre (AMC) Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11197.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01369.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10311.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2002.tb00158.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7457.101"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2000.41.2.209"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12013"},{"key":"e_1_2_5_11_1","first-page":"Cd003263","article-title":"Interventions for vitiligo","volume":"2","author":"Whitton ME","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.031"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08678.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13663","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:45:40Z","timestamp":1695570340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,6]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/jdv.13663"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13663","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,6]]}}}