{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:50Z","timestamp":1791276950950,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006366","name":"Minist\u00e9rio da Educa\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["BEX 4534\/14\u20100"],"award-info":[{"award-number":["BEX 4534\/14\u20100"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["141641 \/ 2013\u20104"],"award-info":[{"award-number":["141641 \/ 2013\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      There is inadequate knowledge on the involvement of oncogenic mechanisms linked to the cyclin (CCND1) gene in lip squamous cell carcinoma (\n                      <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to analyse the implication of cyclin D1 in the malignant transformation of lip lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We immunohistochemically studied 45 actinic cheilitis cases (15 mild dysplasia, 15 moderate dysplasia, 15 severe dysplasia\/carcinoma in situ), 30\n                      <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>\n                      cases with adjacent non\u2010tumour epithelium and 15 normal oral epithelium samples for detection of cyclin D1, \u03b2\u2010catenin and Ki\u201067.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:bold>C<\/jats:bold>\n                      yclin D1 and Ki\u201067 expressions were significantly increased in the basal layer of premalignant epithelia and peripheral layers of tumour nests\n                      <jats:italic>vs<\/jats:italic>\n                      . controls. Premalignant epithelia had lost their asymmetrical proliferative pattern.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lip carcinogenesis was associated with loss of the asymmetrical proliferative pattern, a preventive mechanism against lip oncogenesis, and with cyclin D1 overexpression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.13671","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T03:47:16Z","timestamp":1465789636000},"page":"1315-1320","source":"Crossref","is-referenced-by-count":13,"title":["Asymmetrical proliferative pattern loss linked to cyclin D1 overexpression during malignant transformation of the lip epithelium"],"prefix":"10.1111","volume":"30","author":[{"given":"N.G.","family":"Garcia","sequence":"first","affiliation":[{"name":"Stomatology Department Area of Pathology Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"},{"name":"Oral Medicine Department School of Dentistry Instituto de Biomedicina University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Gonz\u00e1lez\u2010Moles","sequence":"additional","affiliation":[{"name":"Oral Medicine Department School of Dentistry Instituto de Biomedicina University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ruiz\u2010\u00c1vila","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Anatom\u00eda Patol\u00f3gica Instituto de Biomedicina de Granada Complejo Hospitalario san Cecilio Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bravo","sequence":"additional","affiliation":[{"name":"Oral Medicine Department School of Dentistry Instituto de Biomedicina University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ramos\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Oral Medicine Department School of Dentistry Instituto de Biomedicina University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Minicucci","sequence":"additional","affiliation":[{"name":"Pathology Department Botucatu School of Medicine State University of S\u00e3o Paulo Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.C.","family":"Domingues","sequence":"additional","affiliation":[{"name":"Pathology Department Botucatu School of Medicine State University of S\u00e3o Paulo Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.T.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Stomatology Department Area of Pathology Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01611.x"},{"key":"e_1_2_5_3_1","first-page":"140","volume-title":"World Health Organization Classification of Tumours. 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