{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:32:35Z","timestamp":1784752355218,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few epidemiologic data are available regarding biologic liver abnormalities during psoriasis flares.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to assess the prevalence of biological liver test abnormalities (LTA) in a psoriasis population and the risk factors associated with LTA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cross\u2010sectional study in four hospital dermatology tertiary care centres included patients admitted for severe psoriasis flare between 1st January 2010 and 31st December 2011. During the same period, a control population was selected comprising patients admitted for contact and\/or atopic eczema. Data were collected on hospital records and biology software. LTA was defined as serum AST and\/or ALT and\/or ALP concentration above the upper normal limit (UNL) and\/or GGT concentration above 2 UNL. Prevalence of LTA with 95% confidence intervals (95% CI) was compared between the psoriatic and control populations. Factors associated with LTA at <jats:italic>P<\/jats:italic> &lt; 0.05 were considered for the final multivariate logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and forty psoriasis patients and 96 eczema control patients were included. One hundred and fifty\u2010five(64.6%) of the psoriasis patients were male, aged 55 years on average (\u00b117.6); 192 (80.0%) had plaque\u2010type psoriasis (PV) and 52 (21.6%) had localized (<jats:italic>n<\/jats:italic> = 32) or generalized (<jats:italic>n<\/jats:italic> = 20) pustular psoriasis (PP). Prevalence of LTA was 36% (95% CI, 30\u201342) in the psoriatic population, significantly higher than in controls (17%, 95% CI 9.5\u201325). Risk factors independently associated with LTA comprised PV (OR 3.79; 95% CI 1.48\u20139.65), PP (OR 3.80; 95% CI 1.40\u201310.25) and previously diagnosed liver disease (underlying hepatic steatosis, viral hepatitis or excessive alcohol consumption) (OR 3.88; 95% CI 2.02\u20137.45). No association was found with systemic antipsoriatic drug therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In severe psoriasis, liver impacting comorbidities and\/or specific psoriatic inflammation, the latter mostly in PP cases, more than drug\u2010related liver toxicity, appears to predominantly account for LTA. Clinicians should be aware of this, to avoid unjustified withdrawal of useful systemic drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13674","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T13:13:45Z","timestamp":1464268425000},"page":"1742-1748","source":"Crossref","is-referenced-by-count":13,"title":["Liver test abnormalities in patients admitted for severe psoriasis: prevalence and associated risk factors"],"prefix":"10.1111","volume":"30","author":[{"given":"A.","family":"Finet","sequence":"first","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Diderot Paris France"},{"name":"Service de Dermatologie AP\u2010HP H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Viguier","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Diderot Paris France"},{"name":"Service de Dermatologie AP\u2010HP H\u00f4pital 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Chosidow","sequence":"additional","affiliation":[{"name":"Inserm, Centre d'Investigation Clinique 1430 Cr\u00e9teil France"},{"name":"EA EpidermE 7379 Universit\u00e9 Paris\u2010Est Cr\u00e9teil Cr\u00e9teil France"},{"name":"D\u00e9partement de Dermatologie AP\u2010HP, H\u00f4pital Universitaire Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bachelez","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Diderot Paris France"},{"name":"Service de Dermatologie AP\u2010HP H\u00f4pital Saint\u2010Louis Paris France"},{"name":"INSERMU1163 Institut Imagine, Necker Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sbidian","sequence":"additional","affiliation":[{"name":"Inserm, Centre d'Investigation Clinique 1430 Cr\u00e9teil France"},{"name":"EA 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