{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:09:15Z","timestamp":1783152555658,"version":"3.54.6"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fox\u2013Fordyce Disease (<jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content>) is a rare chronic inflammatory skin disease of the apocrine glands, mainly affecting post\u2010pubertal women. It involves apocrine gland\u2010bearing areas including the axilla, areola, anogenital area and umbilicus. <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content> induced by laser hair removal is a newly reported entity of unknown pathogenesis. To the best of our knowledge, there are only four reported cases in the literature describing a total of four patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We are reporting the first case series of laser\u2010induced <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content> with a histopathological and clinical evaluation of the reported cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A review of the available literature to date about laser\u2010induced <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content> was performed. Clinical and histopathological features were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our case series, the clinical and histological appearance of <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content> following laser hair removal is similar to that of classic <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content>. Exacerbating factors were present in two patients, and were similar to that of classic <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content>. The main histopathological features included dilatation of the follicular infundibulum, follicular hyperkeratosis, dyskeratosis in the follicular infundibulum, periductal lymphohistiocytic infiltrate and perifollicular fibrosis. Two of the four reported cases as well as one of our patients had no perifollicular xanthomatous inflammation, a hallmark feature of classic <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content>. Mast cells were absent in all reported cases, as well as in our patients.<\/jats:p><jats:p>Conclusion: We believe that laser\u2010induced <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content> is under\u2010diagnosed as a newly reported adverse event of laser hair removal. It is clinically and histopathologically similar to classic <jats:styled-content style=\"fixed-case\">FFD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13680","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T16:44:57Z","timestamp":1462207497000},"page":"1578-1582","source":"Crossref","is-referenced-by-count":11,"title":["Fox\u2013Fordyce Disease: An under\u2010diagnosed adverse event of laser hair removal?"],"prefix":"10.1111","volume":"30","author":[{"given":"R.","family":"Sammour","sequence":"first","affiliation":[{"name":"Division of Dermatology St Georges University Hospital Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nasser","sequence":"additional","affiliation":[{"name":"Division of Pathology Clemenceau Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Debahy","sequence":"additional","affiliation":[{"name":"Division of Dermatology St Georges University Hospital Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"El Habr","sequence":"additional","affiliation":[{"name":"Division of Dermatology St Georges University Hospital Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2011.03.005"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.103"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.925"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1263-4"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.854630"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1976.tb04390.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1956.01550010040004"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90015-X"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1999)25:5<451::AID-LSM13>3.0.CO;2-O"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90111-5"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10047"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/146288300750163754"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1954.56"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.8.1020"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13680","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.13680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.13680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:47:22Z","timestamp":1695570442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.13680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/jdv.13680"],"URL":"https:\/\/doi.org\/10.1111\/jdv.13680","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,2]]}}}