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Usually the disease has a benign course with spontaneous remission within a few weeks. Nevertheless, recurrences are quite frequent and may occur for several years. The objective of this study was to review the so far reported treatment options for Wells syndrome in a systematic manner. This systematic review is based on a search on Medline, Embase and Cochrane Central Register for English and German articles from 1970 to 2015. Advices on the treatment of Wells syndrome are limited predominately to case reports or to small case series. There are no randomized controlled trials, and control groups are missing. A variety of treatment options for Wells syndrome were reported including topical and systemic corticosteroids, antihistamines, cyclosporine, dapsone, azathioprine, griseofulvin, doxycycline, minocycline, antimalarial medications, oral tacrolimus\/topical tacrolimus, sulfasalazine, interferon alpha and gamma, TNF alpha inhibitors, colchicine and PUVA therapy. As well\u2010designed, randomized controlled trials are missing, no guidelines for the treatment of this disease can be given. Due to the small number of patients and the frequent misdiagnosis of this clinical entity, the aim of this systematic overview is to call attention to this rare condition and to help clinicians to diagnose and treat Wells syndrome effectively. Due to the good prognosis and tendency to resolve, systemic treatment should be limited to cases resistant to local therapy or with widespread lesions.<\/jats:p>","DOI":"10.1111\/jdv.13706","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T03:43:18Z","timestamp":1467258198000},"page":"1465-1479","source":"Crossref","is-referenced-by-count":71,"title":["Treatment of eosinophilic cellulitis (Wells syndrome) \u2013 a systematic review"],"prefix":"10.1111","volume":"30","author":[{"given":"F.","family":"R\u00e4\u00dfler","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Hautkrankheiten Universit\u00e4tsklinikum Jena Deutschland"},{"name":"Department of Dermatology University Hospital Jena Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Luk\u00e1cs","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hautkrankheiten Universit\u00e4tsklinikum Jena Deutschland"},{"name":"Department of Dermatology University Hospital Jena Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Elsner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hautkrankheiten Universit\u00e4tsklinikum Jena Deutschland"},{"name":"Department of Dermatology University Hospital Jena Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"46","article-title":"Recurrent granulomatous dermatitis with eosinophilia","volume":"57","author":"Wells GC","year":"1971","journal-title":"Trans St Johns Hosp Dermatol Soc"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/archderm.1979.04010050045016","article-title":"Wells' syndrome. 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