{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:54:00Z","timestamp":1791276840227,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cholinergic urticaria (CholU) is a frequent chronic urticaria disorder with itchy weal and flare\u2010type skin reactions in response to physical exercise or passive warming. A higher frequency of atopy among CholU patients has been reported, but the significance of this observation is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence and relevance of atopy in CholU patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty CholU patients were assessed for atopic skin diathesis (atopic predisposition) by use of the Erlangen Atopy Score and divided into atopic and non\u2010atopic predisposed CholU individuals. Both groups were assessed for disease severity (CholUSI) and activity (CholUAS7), quality of life impairment [Dermatology Life Quality Index (DLQI) and CU\u2010Q\n                      <jats:sub>2<\/jats:sub>\n                      OL], seasonal exacerbation, total and specific serum IgE and comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CholU patients were found to exhibit high rates of atopic predisposition (57%), with higher prevalence and scores in female than in male patients. High Erlangen Atopy Scores were linked to high CholU severity, activity and impact on QoL. Atopic predisposed CholU patients show different seasonal exacerbation patterns, IgE specificity and comorbidity profiles as compared to non\u2010atopic CholU patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Atopic predisposition and cholinergic urticaria appear to be linked more closely than previously thought, which suggests shared pathogenetic mechanisms. Atopic patients with cholinergic urticaria have more severe disease and poorer quality of life than those who do not. Thus, all cholinergic urticaria patients should be assessed for atopic predisposition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.13765","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T04:56:13Z","timestamp":1466571373000},"page":"2060-2065","source":"Crossref","is-referenced-by-count":40,"title":["Atopic predisposition in cholinergic urticaria patients and its implications"],"prefix":"10.1111","volume":"30","author":[{"given":"S.","family":"Altrichter","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.K.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2013.09.010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70267-5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1968.tb11948.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED.173.2.217"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12765"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e31825a72fc"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0038-x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-RAI-0485"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2340\/0001555560373380","article-title":"Experimental investigations on the trigger mechanism of the generalized type of heat and cold urticaria by means of a climatic chamber","volume":"60","author":"Illig L","year":"1980","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/273473a0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2340\/0001555570208211","article-title":"Changes in muscarinic acetylcholine receptor binding in skin slices of cholinergic urticaria","volume":"70","author":"Haustein UF","year":"1990","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00509213"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660280064024"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(94)90088-4"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-OA-0611"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320233"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01591.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(96)00119-9"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02177.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.04.007"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12313"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00833.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01920.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02580.x"},{"key":"e_1_2_5_27_1","unstructured":"FreundHG.\u201cEinfluss von Levocetirizin auf den Juckreiz und Hautzustand bei Patienten mit atopischer Dermatitis\u201d.2010. 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