{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:14:46Z","timestamp":1784128486713,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to compare the clinical therapeutic efficacy of topical applications of chamomile vs. a placebo for treating oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blind study, randomly divided 60 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> into two groups, 30 treated with 2% <jats:italic>Chamaemelum nobile<\/jats:italic> gel (0.5 mL\/3 times a day) and 30 treated with a placebo (Trial Registration <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02421770). A visual analogue scale was used to rate pain, itching and burning sensation, and Thongprasom Index, the Oral Health Impact Profile 14 (<jats:styled-content style=\"fixed-case\">OHIP<\/jats:styled-content>\u201014) and the Hospital Anxiety\u2010Depression Scale. Patients were evaluated at baseline and after 4 weeks of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients treated with chamomile showed significant improvements after 4 weeks for pain (<jats:italic>P<\/jats:italic> &lt; 0.001), burning sensation (<jats:italic>P<\/jats:italic> &lt; 0.001), itching (<jats:italic>P<\/jats:italic> = 0.011), <jats:styled-content style=\"fixed-case\">OHIP<\/jats:styled-content>\u201014 (<jats:italic>P<\/jats:italic> &lt; 0.001) and Thongprasom index (<jats:italic>P<\/jats:italic> = 0.001); 92% of patients treated with chamomile showed a partial or total response, while only five subjects (17%) in the placebo group showed any improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The topical application of 2% chamomile gel is an effective treatment for <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13770","type":"journal-article","created":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T07:06:56Z","timestamp":1466492816000},"page":"1783-1786","source":"Crossref","is-referenced-by-count":34,"title":["Efficacy of topical chamomile management vs. placebo in patients with oral lichen planus: a randomized double\u2010blind study"],"prefix":"10.1111","volume":"30","author":[{"given":"P.","family":"Lopez Jornet","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Faculty of Medicine and Dentistry University of Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Aznar\u2010Cayuela","sequence":"additional","affiliation":[{"name":"Colaborate Department of Oral Medicine Faculty of Medicine and Dentistry University of Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2012.01953.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200001050-00004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10821.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12083"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1999.tb00301.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00130.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0302"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.79103"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000194"},{"key":"e_1_2_5_11_1","first-page":"612","article-title":"Clinical evaluation of fluid extract of Chamomilla recutita for oral aphthae","volume":"5","author":"Ramos\u2010e\u2010Silva M","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51472"},{"key":"e_1_2_5_13_1","first-page":"E310","article-title":"Oral lichen planus and oral lichenoid lesions; 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