{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:04:37Z","timestamp":1768536277701,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T00:00:00Z","timestamp":1471046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of the short\u2010pulsed 1064\u2010nm\u2010Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser in treating onychomycosis has been the subject of controversial discussion ever since it received <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content> approval in 2010. Research to date provides no valid conclusions supporting its use from an evidence\u2010based perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this prospective randomized controlled pilot study, we analysed the effect of the short\u2010pulsed 1064\u2010nm\u2010Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser on the rate of mycological remission and clinical improvement after excluding relevant confounders with regard to our previous studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Twenty patients with a total of 82 mycotic toenails were randomized to the treatment group (short\u2010pulsed 1064\u2010nm\u2010Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser) or control group (no laser treatment). We conducted four laser treatments at 4\u2010 to 6\u2010week intervals. In both groups, a local antimycotic agent was applied to the sole of the foot, the area between the toes and the skin directly surrounding the nails. The primary endpoint was complete remission of the onychomycosis after 12 months (fungal culture and histology); secondary endpoints included clinical improvement (Onychomycosis Severity Index, <jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content>) and the occurrence of pain or other adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mycological remission was not achieved in either study group. A comparison of both groups yielded no difference in the <jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content> score, both at the beginning of the trial (<jats:italic>P<\/jats:italic> = 0.9873) and after 12 months (<jats:italic>P<\/jats:italic> = 0.4317). In the treatment group, the <jats:styled-content style=\"fixed-case\">OSI<\/jats:styled-content> score worsened by a mean 2.0 points, and in the control group, by a mean 3.5 points. On a visual analogue scale (0 = \u2018no pain\u2019 to 10 = \u2018most intense pain\u2019), pain in the treatment group was indicated at a mean score of five. Other adverse events were not reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The short\u2010pulsed 1064\u2010nm\u2010Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser shows no long\u2010term efficacy as a monotherapy. Its role as an adjuvant therapy should be investigated in upcoming trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13798","type":"journal-article","created":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T11:10:39Z","timestamp":1471086639000},"page":"175-180","source":"Crossref","is-referenced-by-count":35,"title":["Treating onychomycosis with the short\u2010pulsed 1064\u2010nm\u2010Nd:<scp>YAG<\/scp> laser: results of a prospective randomized controlled trial"],"prefix":"10.1111","volume":"31","author":[{"given":"S.","family":"Karsai","sequence":"first","affiliation":[{"name":"Department of Dermatology Darmstadt hospital Darmstadt Germany"},{"name":"Department of Dermatology Greifswald University Hospital Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Laser clinic Karlsruhe Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Oesterhelt","sequence":"additional","affiliation":[{"name":"Laser clinic Karlsruhe Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Departments of Medical Statistics, Biomathematics and Information Processing Medical Faculty of Heidelberg University Mannheim University Hospital Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.W.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Faculty of Heidelberg University Mannheim University Hospital Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"J\u00fcnger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Greifswald University Hospital Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Raulin","sequence":"additional","affiliation":[{"name":"Laser clinic Karlsruhe Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"US FDA Medical Device 510(k) Clearances. 510(k) number: K093547. Decision date: October 15 2010. PinPointe FootLaser PinPointe USA Inc. [WWW document]2010. URLhttp:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf9\/K093547.pdf(last accessed: 25 October 2015)."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12425"},{"key":"e_1_2_7_4_1","unstructured":"Evaluation Study for the Efficacy and Safety of PinPointe FootLaser in Treatment for Onychomycosis. [WWW document]. 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