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Our aim was to establish a position statement for the management of adults with<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>based on the best available evidence. We searched<jats:italic>PubMed<\/jats:italic>for all reports on randomized controlled trials for the treatment of<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>published in the past 30 years. We retrieved 14 articles reporting randomized controlled trials, and found five which met our quality requirements for in\u2010depth analyses. Erythromycin was found in a well\u2010conducted triple\u2010blind study to cast significant impacts on clinical outcomes. However, adverse gastrointestinal effects were fairly common. Another well\u2010conducted study on azithromycin reported no significant benefit. It was reported in three well\u2010conducted studies on oral acyclovir in low dose (400 mg three times daily for 7 days or 400 mg five times daily for 7 days) and high dose (800 mg five times daily for 7 days), that acyclovir is effective in attaining rash regression and lessening the pruritus. When compared against each other, the high\u2010dose regimen demonstrated no benefit over the low\u2010dose regimens. Our statement comprises the follows: (i) The diagnosis of<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>should be ascertained; (ii) The patients should be assessed for rash severity and impacts on quality of life; (iii)<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>is a self\u2010limiting disease, and most patients do not necessitate any treatment; (iv) For patients necessitating active treatment, oral acyclovir as 400 mg three times daily for 7 days can be considered; (v) Attention should be given to adverse effects and contraindications of acyclovir; (vi) When<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>occurs in early pregnancy, oral antiviral therapy could be considered after consulting experienced clinicians; (vii) Inadequate information exists in the use of acyclovir to treatment<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>in children and breastfeeding women; and (viii) Treating<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>is an off\u2010label use of acyclovir, and this has to be discussed with experienced colleagues and the patients.<\/jats:p>","DOI":"10.1111\/jdv.13826","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T09:31:25Z","timestamp":1468402285000},"page":"1670-1681","source":"Crossref","is-referenced-by-count":26,"title":["A position statement on the management of patients with pityriasis rosea"],"prefix":"10.1111","volume":"30","author":[{"given":"A.","family":"Chuh","sequence":"first","affiliation":[{"name":"JC School of Public Health and Primary Care The Chinese University of Hong Kong and Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Zawar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Godavari Foundation Medical College and Research Center DUPMCJ Nashik 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