{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:29:36Z","timestamp":1791289776063,"version":"4.3.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Some dermatologic entities are strongly associated with the presence of a monoclonal gammopathy. They should be referred to as monoclonal gammopathy of cutaneous significance (\n                    <jats:styled-content style=\"fixed-case\">MGCS<\/jats:styled-content>\n                    ). A short review of the main entities that fit into the spectrum of\n                    <jats:styled-content style=\"fixed-case\">MGCS<\/jats:styled-content>\n                    is provided. Amyloidosis, macroglobulinoderma and follicular hyperkeratotic spicules result from\n                    <jats:italic>extravascular immunoglobulin or immunoglobulin\u2010related protein deposition<\/jats:italic>\n                    . Skin findings include papules and plaques, follicular spicules, purpura, haemorrhagic bullae, macroglossia and nail changes. The skin findings in cryoglobulinemia (\n                    <jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content>\n                    ) result from\n                    <jats:italic>vascular immunoglobulin deposition<\/jats:italic>\n                    , either as immune complexes within the vessel walls in mixed\n                    <jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content>\n                    or within the lumina of small vessels in monoclonal\n                    <jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content>\n                    . Mixed\n                    <jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content>\n                    manifests as palpable purpura of leukocytoclastic vasculitis, and monoclonal\n                    <jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content>\n                    as stellar and\/or retiform purpura that can evolve into extensive skin necrosis. In some rare instances, immunoglobulins have a\n                    <jats:italic>specific biological activity<\/jats:italic>\n                    . This is, for example, the case when they bind lipoproteins that precipitate and induce hypocomplementemic xanthomas. Xanthoderma related to antiflavin activity of the monoclonal component or acquired angioedema related to anti\u2010C1\n                    <jats:styled-content style=\"fixed-case\">INH<\/jats:styled-content>\n                    activity is other example.\n                    <jats:italic>Abnormal cytokine secretion<\/jats:italic>\n                    is the hallmark of some entities. High vascular endothelial growth factor levels correlate with some of the skin manifestations of the Polyneuropathy organomegaly endocrinopathy monoclonal component skin changes syndrome, such as hypertrichosis or the adenopathy and extensive skin patch overlying plasmacytoma syndrome. All the clinical manifestations of the Schnitzler syndrome are\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20101 mediated. In other\n                    <jats:styled-content style=\"fixed-case\">MGCS<\/jats:styled-content>\n                    , such as scleromyxedema, Clarkson syndrome,\n                    <jats:styled-content style=\"fixed-case\">TEMPI<\/jats:styled-content>\n                    syndrome, cutis laxa and the neutrophilic dermatoses, the link between the monoclocal component and the entity is clearly established, but not understood so far.\n                  <\/jats:p>","DOI":"10.1111\/jdv.13847","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T16:33:56Z","timestamp":1470674036000},"page":"45-52","source":"Crossref","is-referenced-by-count":98,"title":["Monoclonal gammopathy of cutaneous significance: review of a relevant concept"],"prefix":"10.1111","volume":"31","author":[{"given":"D.","family":"Lipsker","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Strasbourg et Clinique Dermatologique H\u00f4pitaux Universitaires de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa01133202"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-445304"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-495929"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.408"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.134"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000201"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2007.01.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197507000-00001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12050"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70434-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23828"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.9.1157"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00068-X"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb01163.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063918"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90852-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13196"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197601222940401"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-356907"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01124-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009157"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.100"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24171"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200301000-00005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-38"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200101000-00004"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08251.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0696-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02997.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02100-5"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.01.007"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.26"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.08.015"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-375816"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1106670"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.031"}],"container-title":["Journal 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