{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:37:36Z","timestamp":1793572656386,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008271","name":"LEO Pharma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a lack of response data for topical treatments for psoriasis vulgaris in Asian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the optimal maintenance regimen for topical treatment with calcipotriol monohydrate\/betamethasone dipropionate gel in Korean patients with psoriasis vulgaris, by comparing the efficacy of three 8\u2010week maintenance regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicentre, prospective, randomized, controlled, parallel\u2010group, open\u2010label, phase 4 clinical trial, conducted in South Korea. Patients with psoriasis vulgaris on the limbs\/trunk received once\u2010daily treatment with calcipotriol monohydrate (50 \u03bcg\/g)\/betamethasone dipropionate (500 \u03bcg\/g) gel for 8 weeks (induction phase). Responders (defined as an Investigator's Global Assessment of Disease Severity (<jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content>) grade of \u2018clear\u2019 or \u2018almost clear\u2019) were then randomized to receive 8 weeks\u2019 maintenance treatment with Xamiol<jats:sup>\u00ae<\/jats:sup> gel once daily as needed [pro re nata (PRN Group)], once daily every day (Continuous group), or twice weekly \u2013 on Saturday and Sunday (Weekend group). The primary endpoint was the percentage of <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> responders at week 16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the induction phase, 62.18% of patients were <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> responders. At the end of the maintenance phase (week 16), the responder rate was 63.89% for the <jats:styled-content style=\"fixed-case\">PRN<\/jats:styled-content> group, 67.5% for the Continuous group and 31.43% for the Weekend group. The <jats:styled-content style=\"fixed-case\">PRN<\/jats:styled-content> and Continuous groups were statistically superior to the Weekend group (<jats:italic>P<\/jats:italic> = 0.0109 and <jats:italic>P<\/jats:italic> = 0.0015), but the <jats:styled-content style=\"fixed-case\">PRN<\/jats:styled-content> and Continuous groups did not differ statistically. The incidence of adverse events did not differ significantly between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among Korean patients with psoriasis vulgaris, maintenance treatment with calcipotriol monohydrate\/betamethasone dipropionate using a continuous daily regimen or an \u2018as needed\u2019 daily regimen provided similar efficacy, whereas a twice\u2010weekly regimen was significantly less efficacious than either of these regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13865","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T10:22:59Z","timestamp":1476354179000},"page":"483-489","source":"Crossref","is-referenced-by-count":12,"title":["Optimal maintenance treatment with calcipotriol\/betamethasone dipropionate gel in Korean patients with psoriasis vulgaris: a multicentre randomized, controlled clinical trial"],"prefix":"10.1111","volume":"31","author":[{"given":"J.\u2010H.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010J.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bucheon St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u2010Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology St. Mary's Hospital The Catholic University of Korea Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010B.","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Konkuk University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.\u2010I.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Kyung Hee University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010J.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology Guro Hospital College of Medicine Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010I.","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Medical Center Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010W.","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam South 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the Management of Psoriasis Vulgaris: summary of recommendations for management in primary healthcare setting","volume":"9","author":"Choon S","year":"2014","journal-title":"Malays Fam Physician"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/ddg.12396","article-title":"Topical long\u2010term therapy of psoriasis with vitamin D\u2083 analogues, corticosteroids and their two compound formulations: position paper on evidence and use in daily practice","volume":"12","author":"Augustin M","year":"2014","journal-title":"J Dtsch Dermatol 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